Effects of protein-calorie restriction on mechanical function of hypertrophied cardiac muscle

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dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorGeorgette, José Carlos [UNESP]
dc.contributor.authorAragon, Flávio Ferrari [UNESP]
dc.contributor.authorOkoshi, Marina Politi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:33:02Z
dc.date.available2014-05-20T13:33:02Z
dc.date.issued1999-04-01
dc.description.abstractOBJECTIVE: To assess the effect of food restriction (FR) on hypertrophied cardiac muscle in spontaneously hypertensive rats (SHR). METHODS: Isolated papillary muscle preparations of the left ventricle (LV) of 60-day-old SHR and of normotensive Wistar-Kyoto (WKY) rats were studied. The rats were fed either an unrestricted diet or FR diet (50% of the intake of the control diet) for 30 days. The mechanical function of the muscles was evaluated through monitoring isometric and isotonic contractions. RESULTS: FR caused: 1) reduction in the body weight and LV weight of SHR and WKY rats; 2) increase in the time to peak shortening and the time to peak developed tension (DT) in the hypertrophied myocardium of the SHR; 3) diverging changes in the mechanical function of the normal cardiac muscles of WKY rats with reduction in maximum velocity of isotonic shortening and of the time for DT to decrease 50% of its maximum value, and increase of the resting tension and of the rate of tension decline. CONCLUSION: Short-term FR causes prolongation of the contraction time of hypertrophied muscles and paradoxal changes in mechanical performance of normal cardiac fibers, with worsening of the shortening indices and of the resting tension, and improvement of the isometric relaxation.en
dc.description.affiliationUniversidade Estadual Paulista Instituto de Biociências Faculdade de Medicina de Botucatu
dc.description.affiliationUnespUniversidade Estadual Paulista Instituto de Biociências Faculdade de Medicina de Botucatu
dc.format.extent436-440
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X1999000400004
dc.identifier.citationArquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 72, n. 4, p. 436-440, 1999.
dc.identifier.doi10.1590/S0066-782X1999000400004
dc.identifier.fileS0066-782X1999000400004.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes9418970103564137
dc.identifier.lattes8727897080522289
dc.identifier.lattes4463138671998432
dc.identifier.scieloS0066-782X1999000400004
dc.identifier.urihttp://hdl.handle.net/11449/11295
dc.language.isoeng
dc.publisherSociedade Brasileira de Cardiologia (SBC)
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectfood restrictionen
dc.subjectmyocardial functionen
dc.subjectspontaneously hypertensive raten
dc.titleEffects of protein-calorie restriction on mechanical function of hypertrophied cardiac muscleen
dc.typeArtigo
unesp.author.lattes9418970103564137[1]
unesp.author.lattes8727897080522289[2]
unesp.author.lattes4463138671998432
unesp.author.orcid0000-0002-4402-6523[1]
unesp.author.orcid0000-0002-7719-9682[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB
Artigos - Bioestatística - IBB