Bone healing in critical-size defects treated with either bone graft, membrane, or a combination of both materials: a histological and histometric study in rat tibiae

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dc.contributor.authorBernabe, Pedro Felicio Estrada [UNESP]
dc.contributor.authorNascimento Melo, Luiz Gustavo [UNESP]
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.authorGomes-Filho, Joao Eduardo [UNESP]
dc.contributor.authorDezan Júnior, Eloi [UNESP]
dc.contributor.authorNagata, Maria José Hitomi [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:31:03Z
dc.date.accessioned2014-05-20T13:44:32Z
dc.date.available2013-09-30T18:31:03Z
dc.date.available2014-05-20T13:44:32Z
dc.date.issued2012-03-01
dc.description.abstractObjectives: The aim of the present investigation was to histologically analyze the effect of using lyophilized bovine bone (GenOx (R) organic matrix) with (or without) guided tissue regeneration (using a decalcified cortical osseous membrane [GenDerm (R)]) on bone healing in surgically created critical-size defects created in rat tibia.Material and methods: Surgical critical-size bone defects were created in 64 animals that were randomly divided into four groups: group I (control); group II (defect filled with GenOx (R)); group III (defect covered by GenDerm (R)); group IV (defect filled with GenOx (R) and covered by GenDerm (R)). Animals were killed at 30 or 90 days post-surgery. The specimens were embedded in paraffin, serially cut, and stained with hematoxylin and eosin for analysis under light microscopy. The formation of new bone in the cortical area of the defect was histomorphometrically evaluated.Results: All experimental groups demonstrated superior bone healing compared with the control group. However, group IV samples showed evidence of more advanced healing at both 30 and 90 days post-surgery as compared with the other experimental groups.Conclusions: The bovine organic bone graft GenOx (R) associated with GenDerm (R) this produced the best treatment results in the case of critical-size defects in rat tibia.en
dc.description.affiliationUniv Estadual Paulista, Dept Endodont, Aracatuba Sch Dent, Aracatuba, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Dept Periodont, Aracatuba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Endodont, Aracatuba Sch Dent, Aracatuba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Periodont, Aracatuba, SP, Brazil
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.format.extent384-388
dc.identifierhttp://dx.doi.org/10.1111/j.1600-0501.2011.02166.x
dc.identifier.citationClinical Oral Implants Research. Malden: Wiley-blackwell, v. 23, n. 3, p. 384-388, 2012.
dc.identifier.doi10.1111/j.1600-0501.2011.02166.x
dc.identifier.issn0905-7161
dc.identifier.lattes9235743081667362
dc.identifier.lattes8813777272581972
dc.identifier.lattes8399870097572073
dc.identifier.urihttp://hdl.handle.net/11449/15610
dc.identifier.wosWOS:000300503800017
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofClinical Oral Implants Research
dc.relation.ispartofjcr4.305
dc.relation.ispartofsjr2,462
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectbone regenerationen
dc.subjectbone substitutesen
dc.subjectguided tissue regenerationen
dc.titleBone healing in critical-size defects treated with either bone graft, membrane, or a combination of both materials: a histological and histometric study in rat tibiaeen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes9235743081667362
unesp.author.lattes8813777272581972
unesp.author.lattes8399870097572073
unesp.author.orcid0000-0003-2348-7846[3]
unesp.author.orcid0000-0001-5994-2287[4]
unesp.author.orcid0000-0001-5903-5652[6]
unesp.author.orcid0000-0002-5699-6578[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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Artigos - Odontologia Restauradora - FOA
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