Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration

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dc.contributor.authorSábio, Rafael Miguel [UNESP]
dc.contributor.authorMeneguin, Andréia Bagliotti [UNESP]
dc.contributor.authorMartins dos Santos, Aline [UNESP]
dc.contributor.authorMonteiro, Andreia Sofia [UNESP]
dc.contributor.authorChorilli, Marlus [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2021-06-25T11:09:36Z
dc.date.available2021-06-25T11:09:36Z
dc.date.issued2021-01-01
dc.description.abstractThe exploitation of mesoporous silica nanoparticles (MSNs) as drug delivery systems has grown exponentially due to their remarkable tunable properties, such as high surface area, chemical and physical stability, high loading and release capacities, distinct possibilities of particle and pore structures, as well as good biocompatibility, biodegradability, and easy clearance. However, the main exposure routes that exploit MSNs qualities, namely intravenous, subcutaneous, intramuscular, intratumoral, ophthalmic, pulmonary, nasal, dermal, and oral administrations, have been underreported to date. In addition, a better understanding of these administration routes can contribute to the development of smart MSNs-based nanoplatforms with interesting properties, such as high stability in physiological media, specificity and efficacy in theranostic applications, and further clinical translations. This review highlights the advantages and challenges of the administration routes aforementioned regarding the MSNs as drug delivery systems. It also shows how their properties can influence the interaction with biological media, and consequently, their biocompatibility, biodistribution, and clearance mostly in pre-clinical assays, in order to contribute to further MSNs-based nanoplatform clinical translations.en
dc.description.affiliationSchool of Pharmaceutical Sciences - São Paulo State University (UNESP)
dc.description.affiliationInstitute of Chemistry - São Paulo State University (UNESP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences - São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Chemistry - São Paulo State University (UNESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCNPq: # 465687/2014-8
dc.description.sponsorshipIdFAPESP: #18/25377-3
dc.description.sponsorshipIdFAPESP: #2014/50928-2
dc.identifierhttp://dx.doi.org/10.1016/j.micromeso.2020.110774
dc.identifier.citationMicroporous and Mesoporous Materials, v. 312.
dc.identifier.doi10.1016/j.micromeso.2020.110774
dc.identifier.issn1387-1811
dc.identifier.scopus2-s2.0-85098475136
dc.identifier.urihttp://hdl.handle.net/11449/208277
dc.language.isoeng
dc.relation.ispartofMicroporous and Mesoporous Materials
dc.sourceScopus
dc.subjectAdministration routes
dc.subjectBiological behavior
dc.subjectDrug delivery systems
dc.subjectMesoporous silica nanoparticles (MSNs)
dc.titleExploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administrationen
dc.typeResenha
unesp.author.orcid0000-0002-6698-0545[5]

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Artigos - Fármacos e Medicamentos - FCFAR