Healing of fresh frozen bone allograft with or without platelet-rich plasma: A histologic and histometric study in rats

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dc.contributor.authorMessora, Michel
dc.contributor.authorBraga, Laís
dc.contributor.authorOliveira, Gabriela
dc.contributor.authorOliveira, Luiz Fernando
dc.contributor.authorMilagres, Roselaine
dc.contributor.authorKawata, Leandro
dc.contributor.authorFurlaneto, Flávia
dc.contributor.authorPola, Natália [UNESP]
dc.contributor.authorCampos, Natália [UNESP]
dc.contributor.authorNagata, Maria [UNESP]
dc.contributor.institutionLavras University Center - UNILAVRAS
dc.contributor.institutionFederal University of Ceara
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:36Z
dc.date.available2014-05-27T11:29:36Z
dc.date.issued2013-06-01
dc.description.abstractPurpose: This study histomorphometrically analyzed the effect of autogenous platelet-rich plasma (PRP) on healing of fresh frozen bone allograft (FFBA) in bony defects in rat calvaria. Materials and Methods: A 5mm-diameter defect was created in the calvarium of 30 rats. Animals were divided into three groups: C (defect was filled by blood clot only), FFBA (defect was filled with 0.01mL of FFBA), and FFBA/PRP (defect was filled with 0.01mL of FFBA combined with 100μL of PRP). All animals were euthanized at 30 days postoperatively. Histomorphometry and histology analyses were performed. Data were statistically analyzed (analysis of variance, Tukey, p<.05). Results: FFBA had a statistically smaller new bone area than groups FFBA/PRP and C. No statistically significant differences were observed between groups FFBA and FFBA/PRP with regard to remaining bone graft particle area. Conclusion: It can be concluded that (1) PRP improved the incorporation of FFBA, increasing the amount of new bone formed; (2) PRP has not influenced the resorption of nonviable particles of the FFBA; and (3) presence of remaining FFBA particles might have accounted for the smaller amount of new bone observed in group FFBA when compared with control group. © 2011 Wiley Periodicals, Inc.en
dc.description.affiliationDivision of Integrated Clinic Dental School of Lavras Lavras University Center - UNILAVRAS, Lavras
dc.description.affiliationDivision of Periodontics Federal University of Ceara, Sobral
dc.description.affiliationDivision of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, UNESP - Univ. Estadual Paulista, Araçatuba
dc.description.affiliationUnespDivision of Periodontics Department of Surgery and Integrated Clinic Dental School of Araçatuba, UNESP - Univ. Estadual Paulista, Araçatuba
dc.format.extent438-447
dc.identifierhttp://dx.doi.org/10.1111/j.1708-8208.2011.00419.x
dc.identifier.citationClinical Implant Dentistry and Related Research, v. 15, n. 3, p. 438-447, 2013.
dc.identifier.doi10.1111/j.1708-8208.2011.00419.x
dc.identifier.issn1523-0899
dc.identifier.issn1708-8208
dc.identifier.scopus2-s2.0-84878813412
dc.identifier.urihttp://hdl.handle.net/11449/75547
dc.identifier.wosWOS:000319994700013
dc.language.isoeng
dc.relation.ispartofClinical Implant Dentistry and Related Research
dc.relation.ispartofjcr3.097
dc.relation.ispartofsjr1,827
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectBone regeneration
dc.subjectHomologous
dc.subjectPlatelet-rich plasma
dc.subjectTransplantation
dc.titleHealing of fresh frozen bone allograft with or without platelet-rich plasma: A histologic and histometric study in ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
unesp.author.orcid0000-0001-9188-7337[8]
unesp.author.orcid0000-0001-8485-9645[1]
unesp.author.orcid0000-0002-8072-3983[7]
unesp.author.orcid0000-0001-7245-5213[9]
unesp.author.orcid0000-0001-5903-5652[10]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araçatubapt

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