A Rat Model of Neurocysticercosis-Induced Hydrocephalus: Chronic Progressive Hydrocephalus with Mild Clinical Impairment

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dc.contributor.authorHamamoto Filho, Pedro Tadao [UNESP]
dc.contributor.authorFogaroli, Marcelo Ortolani [UNESP]
dc.contributor.authorOliveira, Marcelo Augusto Chiantelli [UNESP]
dc.contributor.authorOliveira, Cristiano Claudino [UNESP]
dc.contributor.authorBatah, Sabrina Setembre
dc.contributor.authorFabro, Alexandre Todorovic
dc.contributor.authorVulcano, Luiz Carlos [UNESP]
dc.contributor.authorBazan, Rodrigo [UNESP]
dc.contributor.authorZanini, Marco Antônio [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2020-12-12T01:39:55Z
dc.date.available2020-12-12T01:39:55Z
dc.date.issued2019-12-01
dc.description.abstractBackground: Hydrocephalus is the most common complication of extraparenchymal neurocysticercosis, combining obstructive and inflammatory mechanisms that impair cerebrospinal fluid circulation. Methods: We studied the long-term progression of neurocysticercosis-induced hydrocephalus in a rat model. We generated an experimental rat model of neurocysticercosis-induced hydrocephalus by cisternal inoculation of cysts or antigens of Taenia crassiceps and compared it with the classic model of kaolin-induced hydrocephalus. We used 52 animals divided into 4 groups: 1) control, 2) neurocysticercosis-induced hydrocephalus by cysts or 3) by antigens, and 4) kaolin-induced hydrocephalus. We studied behavioral, radiologic, and morphologic alterations at 1 and 6 months after inoculation by open field test, magnetic resonance imaging, and immunohistochemical localization of aquaporin-4 (AQP-4). Results: Behavioral changes were observed later in neurocysticercosis-induced than in kaolin-induced hydrocephalic rats (P = 0.023). The ventricular volume of hydrocephalus induced by experimental neurocysticercosis progressively evolved, with the magnetic resonance imaging changes being similar to those observed in humans. Periventricular inflammatory and astrocytic reactions were also observed. AQP-4 expression was higher in the sixth than in the first month after inoculation (P = 0.016) and also occurred in animals that received antigen inoculation but did not develop hydrocephalus, suggesting that AQP-4 may constitute an alternative route of cerebrospinal fluid absorption under inflammatory conditions. Conclusions: Our neurocysticercosis-induced hydrocephalus model allows for the long-term maintenance of hydrocephalic animals, involving mild clinical performance impairments, including body weight and behavioral changes.en
dc.description.affiliationDepartment of Neurology Psychology and Psychiatry UNESP–Univ Estadual Paulista Botucatu Medical School
dc.description.affiliationDepartment of Pathology UNESP–Univ Estadual Paulista Botucatu Medical School
dc.description.affiliationDepartment of Pathology and Legal Medicine USP–Univ São Paulo Ribeirão Preto Medical School
dc.description.affiliationDepartment of Animal Reproduction and Veterinary Radiology UNESP–Univ Estadual Paulista School of Veterinary Medicine and Animal Science
dc.description.affiliationUnespDepartment of Neurology Psychology and Psychiatry UNESP–Univ Estadual Paulista Botucatu Medical School
dc.description.affiliationUnespDepartment of Pathology UNESP–Univ Estadual Paulista Botucatu Medical School
dc.description.affiliationUnespDepartment of Animal Reproduction and Veterinary Radiology UNESP–Univ Estadual Paulista School of Veterinary Medicine and Animal Science
dc.format.extente535-e544
dc.identifierhttp://dx.doi.org/10.1016/j.wneu.2019.08.085
dc.identifier.citationWorld Neurosurgery, v. 132, p. e535-e544.
dc.identifier.doi10.1016/j.wneu.2019.08.085
dc.identifier.issn1878-8769
dc.identifier.issn1878-8750
dc.identifier.scopus2-s2.0-85072531797
dc.identifier.urihttp://hdl.handle.net/11449/199444
dc.language.isoeng
dc.relation.ispartofWorld Neurosurgery
dc.sourceScopus
dc.subjectHydrocephalus
dc.subjectKaolin
dc.subjectNeurocysticercosis
dc.subjectTaenia crassiceps
dc.subjectVentricular dilatation
dc.titleA Rat Model of Neurocysticercosis-Induced Hydrocephalus: Chronic Progressive Hydrocephalus with Mild Clinical Impairmenten
dc.typeArtigo

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Artigos - Neurologia, Psicologia e Psiquiatria - FMB
Artigos - Patologia - FMB
Artigos - Reprodução Animal e Radiologia Veterinária - FMVZ