New compounds of Siolmatra brasiliensis and inhibition of in vitro protein glycation damage

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dc.contributor.authordos Santos, Carlos Henrique Corrêa
dc.contributor.authorTalpo, Tassiana Cristina [UNESP]
dc.contributor.authorMotta, Bruno Pereira [UNESP]
dc.contributor.authorKaga, Anderson Kiyoshi [UNESP]
dc.contributor.authorBaviera, Amanda Martins [UNESP]
dc.contributor.authorCastro, Rosane Nora
dc.contributor.authorda Silva, Virgínia Cláudia
dc.contributor.authorde Sousa-Junior, Paulo Teixeira
dc.contributor.authorWessjohann, Ludger
dc.contributor.authorde Carvalho, Mário Geraldo
dc.contributor.institutionUniversidade Federal Rural do Rio de Janeiro
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso
dc.contributor.institutionLeibniz Institute of Plant Biochemistry
dc.date.accessioned2019-10-06T16:12:33Z
dc.date.available2019-10-06T16:12:33Z
dc.date.issued2019-03-01
dc.description.abstractTwenty compounds were isolated from the hydroethanolic extract of the stems of Siolmatra brasiliensis, five flavonoids, two lignans, one glucosyl phytosterol, seven nor-cucurbitacins, one new phenolic derivative named siolmatrin (1) and four new dammarane-type saponins named siolmatrosides II-V (2–5), the structures of the compounds were assigned by means of 1D and 2D NMR experiments and HRESIMS of the natural compounds and some acetyl derivatives. The effects of the crude hydroethanolic extract (SbExt) and the ethyl acetate fraction (SbEtAc) of Siolmatra brasiliensis stems on the formation of advanced glycation end-products (AGEs) were also investigated. In the in vitro model system of protein glycation using bovine serum albumin (BSA) and glucose, addition of SbExt or SbEtAc inhibited the formation of fluorescent AGEs, in parallel to minor levels of fructosamine (SbEtAc) and markers of tyrosine and tryptophan oxidation (SbExt and SbEtAc). Protein crosslinking, which represents changes of late stages of protein glycation, was reduced in the presence of SbExt and SbEtAc. Siolmatra brasiliensis stems seem to be a promising source of compounds having ability to prevent glycoxidation changes, arising as an interesting option to be studied as a complementary therapy for complications of diabetes.en
dc.description.affiliationPrograma de Pós-graduação em Química Instituto de Química Universidade Federal Rural do Rio de Janeiro
dc.description.affiliationDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista UNESP
dc.description.affiliationDepartamento de Química Universidade Federal de Mato Grosso
dc.description.affiliationDepartment of Bioorganic Chemistry Leibniz Institute of Plant Biochemistry
dc.description.affiliationUnespDepartamento de Análises Clínicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista UNESP
dc.format.extent109-119
dc.identifierhttp://dx.doi.org/10.1016/j.fitote.2018.12.023
dc.identifier.citationFitoterapia, v. 133, p. 109-119.
dc.identifier.doi10.1016/j.fitote.2018.12.023
dc.identifier.issn1873-6971
dc.identifier.issn0367-326X
dc.identifier.scopus2-s2.0-85059542610
dc.identifier.urihttp://hdl.handle.net/11449/188575
dc.language.isoeng
dc.relation.ispartofFitoterapia
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAntiglycation activity
dc.subjectCucurbitaceae
dc.subjectDiabetes melittus
dc.subjectPhenolic compounds
dc.subjectSiolmatra brasiliensis
dc.subjectTriterpenoids
dc.titleNew compounds of Siolmatra brasiliensis and inhibition of in vitro protein glycation damageen
dc.typeArtigo
unesp.author.lattes3736475025187750[5]
unesp.author.orcid0000-0001-5039-2485[1]
unesp.author.orcid0000-0003-0987-5295[5]

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Artigos - Análises Clínicas - FCFAR