Effect of single nucleotide polymorphisms of CAPN1 and CAST genes on meat traits in Nellore beef cattle (Bos indicus) and in their crosses with Bos taurus

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dc.contributor.authorCuri, Rogerio Abdallah [UNESP]
dc.contributor.authorChardulo, Luis Artur Loyola [UNESP]
dc.contributor.authorMason, M. C. [UNESP]
dc.contributor.authorArrigoni, Mario de Beni [UNESP]
dc.contributor.authorSilveira, Antonio Carlos [UNESP]
dc.contributor.authorOliveira, Henrique Nunes de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:40:43Z
dc.date.accessioned2014-05-20T13:40:26Z
dc.date.available2013-09-30T18:40:43Z
dc.date.available2014-05-20T13:40:26Z
dc.date.issued2009-08-01
dc.description.abstractP>The objectives of this work were to study the segregation of single nucleotide polymorphisms of the calpain 1, large subunit (CAPN1) and calpastatin (CAST) genes in Nellore (Bos indicus) and Nellore xBos taurus beef cattle, as well as to evaluate their effects on meat traits. For this, 300 animals, including 114 Nellore, 67 Angus x Nellore, 44 Rubia Gallega x Nellore, 41 Canchim, 19 Brangus three-way crosses and 15 Braunvieh three-way crosses, were genotyped for the CAPN4751 [AF_248054.2:g.6545C > T (GenBank accession AF248054.2)] and CAST/DdeI [AF_159246.1:g.2959A > G (GenBank accession AF159246.1)] polymorphisms and phenotyped for Ribeye Area, Backfat Thickness, Intramuscular Fat, Shear Force (SF) and Myofibrillar Fragmentation Index (MFI). In relation to the CAPN4751 polymorphism, a frequency of 10.5% was observed for the C allele in the Nellore breed. In the total sample of studied animals, a significant association was found between genotypes and meat tenderness, assessed by SF (P = 0.005) and MFI (P = 0.008), with genotype CT being more favourable than TT. For the CAST/DdeI polymorphism, a frequency of 55.7% was found for the A allele in the Nellore breed. In the total sample, a significant association was observed between genotypes and meat tenderness - SF (P = 0.004) and MFI (P = 0.006), with genotype AA being more favourable than AG. The relationship between genotypes and aged meat tenderness in confluence with the distribution of favourable alleles shows great potential for application of the CAPN4751 and CAST/DdeI polymorphisms in the genetic improvement of the Nellore breed, whilst contributing to the validation, in this breed and in its crosses with B. taurus, of the association results previously described in the literature.en
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecnia, Dept Melhoramento & Nutr Anim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecnia, Dept Melhoramento & Nutr Anim, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Quim & Bioquim, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent456-462
dc.identifierhttp://dx.doi.org/10.1111/j.1365-2052.2009.01859.x
dc.identifier.citationAnimal Genetics. Malden: Wiley-blackwell Publishing, Inc, v. 40, n. 4, p. 456-462, 2009.
dc.identifier.doi10.1111/j.1365-2052.2009.01859.x
dc.identifier.issn0268-9146
dc.identifier.lattes9820754011277263
dc.identifier.lattes0555360557852992
dc.identifier.lattes3514713413919126
dc.identifier.orcid0000-0001-6289-0406
dc.identifier.urihttp://hdl.handle.net/11449/14039
dc.identifier.wosWOS:000268028100011
dc.language.isoeng
dc.publisherWiley-Blackwell Publishing, Inc
dc.relation.ispartofAnimal Genetics
dc.relation.ispartofjcr1.841
dc.relation.ispartofsjr0,830
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectcalpainen
dc.subjectcalpastatinen
dc.subjectmeat tendernessen
dc.subjectpolymorphismen
dc.subjectzebuen
dc.titleEffect of single nucleotide polymorphisms of CAPN1 and CAST genes on meat traits in Nellore beef cattle (Bos indicus) and in their crosses with Bos taurusen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell Publishing, Inc
unesp.author.lattes9820754011277263
unesp.author.lattes0555360557852992
unesp.author.lattes3514713413919126[1]
unesp.author.orcid0000-0001-6289-0406[1]
unesp.author.orcid0000-0003-3224-1688[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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Artigos - Melhoramento e Nutrição Animal - FMVZ
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