Effects of Novel 3-dimensional Antibiotic-containing Electrospun Scaffolds on Dentin Discoloration

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dc.contributor.authorPorter, Margaret Louise A.
dc.contributor.authorMuenchow, Eliseu A.
dc.contributor.authorAlbuquerque, Maria T. P. [UNESP]
dc.contributor.authorSpolnik, Kenneth J.
dc.contributor.authorHara, Anderson T.
dc.contributor.authorBottino, Marco C.
dc.contributor.institutionIndiana Univ
dc.contributor.institutionUniv Fed Pelotas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-11-26T15:28:25Z
dc.date.available2018-11-26T15:28:25Z
dc.date.issued2016-01-01
dc.description.abstractIntroduction: Although intracanal application of the triple antibiotic paste (TAP) may offer advantages (eg, disinfection), this practice has been associated with significant drawbacks, including tooth discoloration. In this study, the color change of dentin was monitored during treatment with distinct TAP pastes and novel tubular-shaped 3-dimensional electrospun scaffolds containing minocycline (MINO) or doxycycline (DOX). Methods: Two TAP pastes (TAP(MINO) [MINO, metronidazole, and ciprofloxacin] and TAP(DOX) [DOX, metronidazole, and ciprofloxacin]), 4 scaffold-based groups containing MINO or DOX at distinct concentrations, 1 antibiotic-free scaffold, and 1 untreated group (control) were investigated. Human canines were sectioned at the cementoenamel junction and tubular-shaped scaffolds or paste were placed into the root canals and sealed. Color measurements (CIEL*a*b* parameters) were performed at baseline and after 1, 3, 7, 14, 21, and 28 days. Color changes were expressed as Delta E* values. In addition, scanning electron microscopy and energy-dispersive X-ray spectroscopy were also performed on the specimens after treatment. Data were analyzed using repeated measures analysis of variance (alpha = 0.05). Results: All antibiotic-containing groups led to greater discoloration than the antibiotic-free groups. A severe discoloration occurred after 1 day. At the end of the experiment, antibiotic-treated samples exhibited crusts/agglomerates over the dentin surface, which totally or partially obliterated the dentinal tubules. The presence of MINO resulted in a greater color change than DOX. Conclusions: Scaffolds containing MINO or DOX produced similar color change to dentin when compared with their respective TAP systems, although DOX-related discoloration was less pronounced.en
dc.description.affiliationIndiana Univ, Sch Dent, Dept Biomed & Appl Sci, Indianapolis, IN 46202 USA
dc.description.affiliationIndiana Univ, Sch Dent, Dept Restorat Dent, Indianapolis, IN 46202 USA
dc.description.affiliationIndiana Univ, Sch Dent, Dept Endodont, Indianapolis, IN 46202 USA
dc.description.affiliationIndiana Univ, Sch Dent, Dept Cariol Operat Dent & Dent Publ Hlth, Indianapolis, IN 46202 USA
dc.description.affiliationUniv Fed Pelotas, Sch Dent, Dept Operat Dent, Pelotas, RS, Brazil
dc.description.affiliationUniv Estadual Paulista, Sao Jose Campos Dent Sch, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Sao Jose Campos Dent Sch, Sao Paulo, Brazil
dc.description.sponsorshipInternational Development Funds (IDF) Grant from Indiana University Purdue University (IUPUI/OVCR)
dc.description.sponsorshipIndiana University School of Dentistry (IUSD)
dc.format.extent106-112
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2015.09.013
dc.identifier.citationJournal Of Endodontics. New York: Elsevier Science Inc, v. 42, n. 1, p. 106-112, 2016.
dc.identifier.doi10.1016/j.joen.2015.09.013
dc.identifier.fileWOS000367117100018.pdf
dc.identifier.issn0099-2399
dc.identifier.urihttp://hdl.handle.net/11449/158636
dc.identifier.wosWOS:000367117100018
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Endodontics
dc.relation.ispartofsjr1,585
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectAntibiotic
dc.subjectdiscoloration
dc.subjectdisinfection
dc.subjectelectrospinning
dc.subjectregeneration
dc.subjectscaffold
dc.titleEffects of Novel 3-dimensional Antibiotic-containing Electrospun Scaffolds on Dentin Discolorationen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0001-8740-2464[6]

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