The exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspring

Página do item simplificado
dc.contributor.authorSantos, Alice Hartmann dos
dc.contributor.authorRamos, Aline Camargo
dc.contributor.authorSilveira, Kennia Moura
dc.contributor.authorKiss, Ana Carolina Inhasz [UNESP]
dc.contributor.authorLonghini, Renata
dc.contributor.authorDiniz, Andréa
dc.contributor.authorMello, João Carlos Palazzo de
dc.contributor.authorGerardin, Daniela Cristina Ceccatto
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.date.accessioned2015-10-22T07:08:21Z
dc.date.available2015-10-22T07:08:21Z
dc.date.issued2015-05-26
dc.description.abstractEthnopharmacological relevance: Trichilia catigua is broadly used in folk medicine due to its mental and physical tonic activities and stimulant effects. In animal models, its antidepressant-like effects have been associated with the dopaminergic (DA) system modulation, which has an important role on maternal behavior and male offspring reproductive development.Aim of the study: Since little is known about the adverse effects of the exposure to T. catigua crude extract (CAT) in rats, specially regarding maternal homeostasis and offspring development, the aim of the present study was to evaluate whether CAT exposure may influence maternal toxicity parameters and behavior or disrupt male offspring physical and reproductive development.Material and methods: Dams were treated daily (by gavage) with 400 mg/kg of CAT or vehicle (control=CTR) throughout pregnancy and lactation. Fertility and maternal behavior tests were conducted in dams. Male offspring reproductive and behavioral parameters were analyzed.Results: Dams exposed to CAT showed increased pre- and post-implantation losses rates when compared to CTR group. No significant changes regarding maternal behavior or male offspring parameters were observed.Conclusion: In conclusion, maternal exposure to CAT interfered with implantation during the initial phases of pregnancy but did not induce changes on maternal behavior or male offspring reproductive and behavioral parameters.en
dc.description.affiliationDepartamento de Ciências Fisiológicas, Universidade Estadual de Londrina (UEL), Londrina, PR, Brasil
dc.description.affiliationDepartamento de Fisiologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.affiliationDepartamento de Farmácia, Universidade Estadual de Maringá (UEM), Maringá, PR, Brasil
dc.description.affiliationUnespDepartamento de Fisiologia, Instituto de Biociências de Botucatu (IBB), Universidade Estadual Paulista (UNESP), Botucatu, SP, Brasil
dc.description.sponsorshipFundação Araucária
dc.description.sponsorshipIdFundação Araucária: 467/10
dc.format.extent86-91
dc.identifierhttp://www.sciencedirect.com/science/article/pii/S0378874115001622
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier Ireland Ltd, v. 166, p. 86-91, 2015.
dc.identifier.doi10.1016/j.jep.2015.03.018
dc.identifier.issn0378-8741
dc.identifier.urihttp://hdl.handle.net/11449/129788
dc.identifier.wosWOS:000354009500011
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectTrichilia catiguaen
dc.subjectFertilityen
dc.subjectEmbryotoxicityen
dc.subjectMaternal behavioren
dc.subjectDopamineen
dc.titleThe exposure to Trichilia catigua (catuaba) crude extract impairs fertility of adult female rats but does not cause reproductive damage to male offspringen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes1490222400024738[4]
unesp.author.orcid0000-0002-8558-0141[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt

Arquivos

Coleções

Artigos - Fisiologia - IBB