The expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasis

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dc.contributor.authorOliveira-Neto, Helenisa Helena
dc.contributor.authorSouza, Pedro Paulo Chaves de [UNESP]
dc.contributor.authorDa Silva, Márcio Roberto Barbosa
dc.contributor.authorMendonça, Elismauro Francisco
dc.contributor.authorSilva, Tarcília Aparecida
dc.contributor.authorBatista, Aline Carvalho
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionGoiás Combat Cancer Association
dc.contributor.institutionUniversidade Federal de Minas Gerais (UFMG)
dc.date.accessioned2014-05-27T11:28:17Z
dc.date.available2014-05-27T11:28:17Z
dc.date.issued2013-02-01
dc.description.abstractThe purpose of this study is to determine the expression of CCL19, CCL21, and CCR7 in samples of oral squamous cell carcinoma (OSCC) and their relationship with clinical and microscopic parameters. A comparative analysis was made of the mRNA expression of these chemokines and receptor in OSCC and normal oral mucosa. The immunoexpression of CCR7, CCL19, and CCL21 was also verified in OSCC and lymph nodes. Statistical significance was accepted at P < 0.05. Similar levels of CCR7, CCL19, and CCL21 mRNA in OSCC and normal oral mucosa were seen. A low expression of CCL19 and CCL21 in the intra- and peritumoral regions was observed. Scarce CCL19+ and CCL21+ cells were also noted in metastatic and non-metastatic lymph nodes. No association was found between the expression of these chemokines and clinical and microscopic parameters. Our findings would suggest that CCL19 and CCL21 may not be associated with cervical lymph node metastasis or other clinical and microscopic factors in OSCC. © 2012 International Society of Oncology and BioMarkers (ISOBM).en
dc.description.affiliationDepartment of Stomatology (Oral Pathology) Dental School Federal University of Goiás, Goiânia CEP 74605-220
dc.description.affiliationDepartment of Physiology and Pathology Dental School São Paulo State University, Araraquara São Paulo CEP 14800-901
dc.description.affiliationDivision of Head and Neck Araújo Jorge Hospital Goiás Combat Cancer Association, Goiânia CEP 74605-010
dc.description.affiliationDepartment of Oral Surgery and Pathology Dental School Federal University of Minas Gerais, Belo Horizonte CEP 31270-217
dc.description.affiliationDisciplina de Patologia Geral e Bucal Faculdade de Odontologia Universidade Federal de Goiás, Praça Universitária S/N, Goiânia CEP 74605-220
dc.description.affiliationUnespDepartment of Physiology and Pathology Dental School São Paulo State University, Araraquara São Paulo CEP 14800-901
dc.format.extent65-70
dc.identifierhttp://dx.doi.org/10.1007/s13277-012-0511-3
dc.identifier.citationTumor Biology, v. 34, n. 1, p. 65-70, 2013.
dc.identifier.doi10.1007/s13277-012-0511-3
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.scopus2-s2.0-84872779578
dc.identifier.urihttp://hdl.handle.net/11449/74457
dc.identifier.wosWOS:000313875400009
dc.language.isoeng
dc.relation.ispartofTumor Biology
dc.relation.ispartofsjr1,149
dc.relation.ispartofsjr1,149
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectCCL19
dc.subjectCCL21
dc.subjectCCR7
dc.subjectChemokine
dc.subjectLymph node
dc.subjectMetastasis
dc.subjectOral squamous cell carcinoma
dc.subjectchemokine
dc.subjectchemokine receptor
dc.subjectchemokine receptor CCR7
dc.subjectmacrophage inflammatory protein 3beta
dc.subjectmessenger RNA
dc.subjectmonocyte chemotactic protein 5
dc.subjectadult
dc.subjectaged
dc.subjectcell count
dc.subjectcell proliferation
dc.subjectcervical lymph node
dc.subjectclinical article
dc.subjectclinical feature
dc.subjectcomparative study
dc.subjectcontrolled study
dc.subjectdisease association
dc.subjectfemale
dc.subjecthuman
dc.subjecthuman cell
dc.subjecthuman tissue
dc.subjectlymph node metastasis
dc.subjectmale
dc.subjectmetastasis potential
dc.subjectmouth mucosa
dc.subjectmouth squamous cell carcinoma
dc.subjectnucleotide sequence
dc.subjectoncological parameters
dc.subjectpriority journal
dc.subjectprotein expression
dc.subjectprotein function
dc.subjecttumor localization
dc.subjectCarcinoma, Squamous Cell
dc.subjectChemokine CCL19
dc.subjectChemokine CCL21
dc.subjectFemale
dc.subjectHumans
dc.subjectLymph Nodes
dc.subjectLymphatic Metastasis
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectMouth Neoplasms
dc.subjectReceptors, CCR7
dc.subjectRNA, Messenger
dc.subjectTreatment Outcome
dc.titleThe expression of chemokines CCL19, CCL21 and their receptor CCR7 in oral squamous cell carcinoma and its relevance to cervical lymph node metastasisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights
unesp.author.orcid0000-0002-6751-3279[4]
unesp.author.orcid0000-0002-2117-5593[6]
unesp.author.orcid0000-0001-7266-6061[2]
unesp.author.orcid0000-0001-9623-7835[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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