Mutagenic effect of native species of the Brazilian Cerrado with anti-ulcerogenic activity

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dc.contributor.authorCardoso, Cássia R. P. [UNESP]
dc.contributor.authorTubaldini, Flavio Romanini [UNESP]
dc.contributor.authorRodrigues, Clenilson M. [UNESP]
dc.contributor.authorRinaldo, Daniel [UNESP]
dc.contributor.authorSeveri, Juliana Aparecida [UNESP]
dc.contributor.authorCólus, Ilce Mara S.
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorVaranda, Eliana Aparecida [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.date.accessioned2014-05-27T11:23:49Z
dc.date.available2014-05-27T11:23:49Z
dc.date.issued2008-12-01
dc.description.abstractNeea theifera Oerted (Nyctaginaceae), Guapira noxia Linn. (Nyctaginaceae) and Hancornia speciosa Gomes (Apocynaceae) are plant species found in Brazilian Cerrado used popularly for the treatment of gastric ulcers. Here they are assessed for mutagenic activity by analysis of the reverse mutations induced in Salmonella typhimurium strains TA100, TA98, TA102 and TA97a, by extracts of the plants, with and without metabolic activation. Methanol and chloroform extracts of N. theifera and G. noxia and methanolic and aqueous extracts of H. speciosa were tested at five different concentrations. It was found that only the methanolic extract of H. speciosa exhibited a positive mutagenic effect, on strains TA98 and TA100 in the absence of metabolic activation. The phytochemical analysis of the species suggested that condensed tannins are the main compounds responsible for the observed effect.en
dc.description.affiliationUNESP-São Paulo State University Department of Biological Sciences Faculty of Pharmaceutical Sciences, Araraquara, SP
dc.description.affiliationUNESP-São Paulo State University Institute of Chemistry, Araraquara, SP
dc.description.affiliationUEL-Londrina State University Department of General Biology Biological Sciences Center, PR
dc.description.affiliationUnespUNESP-São Paulo State University Department of Biological Sciences Faculty of Pharmaceutical Sciences, Araraquara, SP
dc.description.affiliationUnespUNESP-São Paulo State University Institute of Chemistry, Araraquara, SP
dc.format.extent31-41
dc.identifier.citationCurrent Topics in Toxicology, v. 5, p. 31-41.
dc.identifier.issn0972-8228
dc.identifier.lattes7501930236496670
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.scopus2-s2.0-84872726125
dc.identifier.urihttp://hdl.handle.net/11449/70858
dc.language.isoeng
dc.relation.ispartofCurrent Topics in Toxicology
dc.relation.ispartofsjr0,122
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAmes test
dc.subjectGuapira noxia
dc.subjectHancornia speciosa
dc.subjectMutagenic activity
dc.subjectNeea theifera
dc.subjectTannins
dc.titleMutagenic effect of native species of the Brazilian Cerrado with anti-ulcerogenic activityen
dc.typeArtigo
unesp.author.lattes7501930236496670
unesp.author.orcid0000-0001-5363-6481[4]
unesp.author.orcid0000-0003-3032-2556[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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