Ultrastructural alterations in colon absorptive cells of alloxan-induced diabetic rats submitted to long-term physical training

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dc.contributor.authorRemedio, Rafael N. [UNESP]
dc.contributor.authorBarbosa, Rodrigo A. [UNESP]
dc.contributor.authorCastellar, Alexandre [UNESP]
dc.contributor.authorGomes, Ricardo J.
dc.contributor.authorCaetano, Flávio Henrique [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2014-05-20T15:32:24Z
dc.date.available2014-05-20T15:32:24Z
dc.date.issued2012-10-01
dc.description.abstractAbsorptive cells have notable importance for proper function of the colon, absorbing water and nutrients. In type I diabetes, hyperglycemia leads to remarkable alterations in cell structure. In absorptive cells, such changes may impair the function of the organ as a whole. Also, the effects of physical training, which plays crucial role in the treatment of diabetes, are not yet known in these cells. For this reason, to analyze the changes in colon epithelial absorptive cells of diabetic rats and the effects of physical training, Wistar rats were divided into four groups: sedentary control (SC), trained control (TC), sedentary diabetic (SD), and trained diabetic (TD). The training protocol consisted of swimming for 60 min a day, 5 days per week, during 8 weeks. Colon samples were collected, processed, and evaluated by histochemical and ultrastructural techniques. Although histochemical analysis did not reveal major differences, significant morphological differences were ultrastructurally observed among groups, especially related to the structure of tight junctions, interdigitations, and microvilli, which became longer in diabetics, and whose length was reduced after physical training, as proved by statistical analysis. There were no relevant changes in organelles. Thus, the development of type I diabetes can lead to changes at ultrastructural level that, even subtle, may cause important alterations in cell function. The practice of physical training, in turn, proved to be an important ally in the treatment of such changes. However, it cannot be used singly for treating this disease, requiring the combined practice of other methods. Microsc. Res. Tech. 2012. (c) 2012 Wiley Periodicals, Inc.en
dc.description.affiliationSão Paulo State Univ UNESP, Dept Biol, São Paulo, Brazil
dc.description.affiliationSão Paulo Fed Univ UNIFESP, Dept Biosci, São Paulo, Brazil
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Biol, São Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1305-1312
dc.identifierhttp://dx.doi.org/10.1002/jemt.22065
dc.identifier.citationMicroscopy Research and Technique. Hoboken: Wiley-blackwell, v. 75, n. 10, p. 1305-1312, 2012.
dc.identifier.doi10.1002/jemt.22065
dc.identifier.issn1059-910X
dc.identifier.lattes4396826019535898
dc.identifier.urihttp://hdl.handle.net/11449/41312
dc.identifier.wosWOS:000309071600001
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofMicroscopy Research and Technique
dc.relation.ispartofjcr1.087
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectdiabetesen
dc.subjectphysical trainingen
dc.subjectlarge intestineen
dc.subjecthistochemistryen
dc.subjectultrastructureen
dc.titleUltrastructural alterations in colon absorptive cells of alloxan-induced diabetic rats submitted to long-term physical trainingen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
unesp.author.lattes4396826019535898
unesp.author.orcid0000-0002-9913-8565[1]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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