Acute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese mice

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dc.contributor.authorGaspar, Rafael Calais
dc.contributor.authorMuñoz, Vitor Rosetto
dc.contributor.authorKuga, Gabriel Keine [UNESP]
dc.contributor.authorNakandakari, Susana Castelo Branco Ramos
dc.contributor.authorMinuzzi, Luciele Guerra
dc.contributor.authorBotezelli, José Diego
dc.contributor.authorda Silva, Adelino S.R.
dc.contributor.authorCintra, Dennys Esper
dc.contributor.authorde Moura, Leandro Pereira
dc.contributor.authorRopelle, Eduardo Rochete
dc.contributor.authorPauli, José Rodrigo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Coimbra
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T16:55:24Z
dc.date.available2018-12-11T16:55:24Z
dc.date.issued2018-01-01
dc.description.abstractThe obesity is a result of energy imbalance and the increase in thermogenesis seems an interesting alternative for the treatment of this disease. The mechanism of energy expenditure through thermogenesis is tightly articulated in the hypothalamus by leptin. The hypothalamic extracellular signal-regulated kinase-1/2 (ERK1/2) is a key mediator of the thermoregulatory effect of leptin and mediates the sympathetic signal to the brown adipose tissue (BAT). In this context, physical exercise is one of the main interventions for the treatment of obesity. Thus, this study aimed to verify the effects of acute physical exercise on leptin-induced hypothalamic ERK1/2 phosphorylation and thermogenesis in obese mice. Here we showed that acute physical exercise reduced the fasting glucose of obese mice and increased leptin-induced hypothalamic p-ERK1/2 and uncoupling protein 1 (UCP1) content in BAT (P < 0.05). These molecular changes are accompanied by an increased oxygen uptake (VO 2) and heat production in obese exercised mice (P < 0.05). The increased energy expenditure in the obese exercised animals occurred independently of changes in spontaneous activity. Thus, this is the first study demonstrating that acute physical exercise can increase leptin-induced hypothalamic ERK1/2 phosphorylation and energy expenditure of obese mice.en
dc.description.affiliationLaboratory of Molecular Biology of Exercise (LaBMEx) University of Campinas (UNICAMP)
dc.description.affiliationDepartment of Physical Education Post-graduate Program in Movement Sciences São Paulo State University (UNESP)
dc.description.affiliationLaboratory of Nutritional Genomics (LabGeN) University of Campinas (UNICAMP)
dc.description.affiliationResearch Center for Sport and Physical Activity (IUD/DTP/04213/2016) Faculty of Sports Science and Physical Education University of Coimbra
dc.description.affiliationSchool of Physical Education and Sports of Ribeirão Preto Post-graduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School USP
dc.description.affiliationLaboratory of Cell Signaling Obesity and Comorbidities Research Center (OCRC) University of Campinas
dc.description.affiliationCEPECE - Center of Research in Sport Sciences School of Applied Sciences University of Campinas (UNICAMP)
dc.description.affiliationUnespDepartment of Physical Education Post-graduate Program in Movement Sciences São Paulo State University (UNESP)
dc.identifierhttp://dx.doi.org/10.1002/jcb.27426
dc.identifier.citationJournal of Cellular Biochemistry.
dc.identifier.doi10.1002/jcb.27426
dc.identifier.issn1097-4644
dc.identifier.issn0730-2312
dc.identifier.scopus2-s2.0-85053379708
dc.identifier.urihttp://hdl.handle.net/11449/171458
dc.language.isoeng
dc.relation.ispartofJournal of Cellular Biochemistry
dc.relation.ispartofsjr1,209
dc.relation.ispartofsjr1,209
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectbrown adipose tissue (BAT)
dc.subjectextracellular signal-regulated kinase-1/2 (ERK1/2)
dc.subjecthypothalamus
dc.subjectobesity
dc.subjectphysical exercise
dc.subjectthermogenesis
dc.subjectUCP1
dc.titleAcute physical exercise increases leptin-induced hypothalamic extracellular signal-regulated kinase1/2 phosphorylation and thermogenesis of obese miceen
dc.typeArtigo
unesp.author.orcid0000-0002-2404-0686[3]

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