Hypothalamic lesions increase saline ingestion induced by injection of angiotensin II into AV3V in rats

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dc.contributor.authorDe Arruda Camargo, L. A. [UNESP]
dc.contributor.authorSaad, W. A. [UNESP]
dc.contributor.authorRenzi, A. [UNESP]
dc.contributor.authorDe Luca, L. A. [UNESP]
dc.contributor.authorGoncalves, J. R. [UNESP]
dc.contributor.authorMenani, J. V. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-28T19:53:49Z
dc.date.available2022-04-28T19:53:49Z
dc.date.issued1991-01-01
dc.description.abstractWater and 3% NaCl intake were increased by the injection of 4 ng angiotensin II (ANG II) into the anteroventral third ventricle (AV3V) region of rats. Pretreatment with two specific ANG II receptor antagonists, [octanoyl-Leu8]ANG II and [Leu8]ANG II, significantly reduced ANG II-induced water and saline intake. This inhibition lasted ~30 min, with partial recovery at 60 min. In rats with electrolytic lesion of the bilateral ventromedial nucleus of hypothalamus (VMH), the effect of ANG II on water intake was not different from that observed in sham rats, but saline ingestion increased. In summary, the present results show that the AV3V region is an important central structure for ANG II-induced saline ingestion. Lesion of the VMH increases the response to ANG II, showing an interaction between the AV3V region and the VMH in the regulation of salt ingestion.en
dc.description.affiliationDept. of Physiology School of Dentistry Paulista State University, 1680 Humaita St., Araraquara, SP, 14800
dc.description.affiliationUnespDept. of Physiology School of Dentistry Paulista State University, 1680 Humaita St., Araraquara, SP, 14800
dc.identifier.citationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology, v. 261, n. 3 30-3, 1991.
dc.identifier.issn0002-9513
dc.identifier.scopus2-s2.0-0026004774
dc.identifier.urihttp://hdl.handle.net/11449/223923
dc.language.isoeng
dc.relation.ispartofAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
dc.sourceScopus
dc.subjectAngiotensin II antagonists
dc.subjectSalt ingestion
dc.subjectWater ingestion
dc.titleHypothalamic lesions increase saline ingestion induced by injection of angiotensin II into AV3V in ratsen
dc.typeArtigo

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