TEMPO-oxidized cellulose poly-ionic drawn fiber, a cell support system proof of concept

Página do item simplificado
dc.contributor.authorRios, Mariana Alves
dc.contributor.authorBarbugli, Paula Aboud [UNESP]
dc.contributor.authorIemma, Mônica Rosas Costa
dc.contributor.authorGrande, Rafael
dc.contributor.authorCarvalho, Antônio José Felix
dc.contributor.authorTrovatti, Eliane
dc.contributor.institutionUniversity of Araraquara
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionAalto Universitty
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2022-04-29T08:31:28Z
dc.date.available2022-04-29T08:31:28Z
dc.date.issued2021-10-01
dc.description.abstractThe development of new cell carrier systems is crucial for application in regenerative medicine, once they deliver the cells to the injured tissue to trigger the repair and stimulate the regeneration. Here we report the preparation of a cell carrier system in fiber shape, in which the cells osteo-1 are incorporated. For the fiber formation, the oxidized cellulose nanofibers suspension loaded with cells is complexed with calcium ions in a pulling process giving rise to the fiber loaded with cells, with dimensions which allow it to handle. The microscopic images showed the success of the proposed method to incorporate the cells into the fibers. The results of the in vitro viability tests indicated the capability of the fibers to keep the cells alive and to mineralize them, indicating that their osteogenic capability was not affected. In addition, the fiber disintegration studies showed the system is capable of releasing the cells, suggesting the potential of the fibers as a new assembled hydrogel carrier cell therapy.en
dc.description.affiliationUniversity of Araraquara, UNIARA, R. Carlos Gomes, 1217
dc.description.affiliationLaboratory of Confocal Microscopy Department of Dental Materials and Prosthodontics Faculty of Dentistry São Paulo State University (Unesp)
dc.description.affiliationDepartment of Bioproducts and Biosystems School of Chemical Engineering Aalto Universitty
dc.description.affiliationDepartment of Materials Engineering Sao Carlos School of Engineering University of Sao Paulo, Av. Joao Dagnone 1100
dc.description.affiliationUnespLaboratory of Confocal Microscopy Department of Dental Materials and Prosthodontics Faculty of Dentistry São Paulo State University (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2017/18782-6
dc.description.sponsorshipIdFAPESP: 2018/06555-8
dc.description.sponsorshipIdCNPq: 303847/2019-0
dc.description.sponsorshipIdCNPq: 307124/2015-0
dc.format.extent16661-16670
dc.identifierhttp://dx.doi.org/10.1007/s10853-021-06373-4
dc.identifier.citationJournal of Materials Science, v. 56, n. 29, p. 16661-16670, 2021.
dc.identifier.doi10.1007/s10853-021-06373-4
dc.identifier.issn1573-4803
dc.identifier.issn0022-2461
dc.identifier.scopus2-s2.0-85111795290
dc.identifier.urihttp://hdl.handle.net/11449/229263
dc.language.isoeng
dc.relation.ispartofJournal of Materials Science
dc.sourceScopus
dc.titleTEMPO-oxidized cellulose poly-ionic drawn fiber, a cell support system proof of concepten
dc.typeArtigo
unesp.author.orcid0000-0002-0495-8115[6]

Arquivos

Coleções

Botucatu - CME - Centro de Microscopia Eletrônica