Antimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system

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dc.contributor.authorCarli, Camila B. de A. [UNESP]
dc.contributor.authorQuilles, Marcela B. [UNESP]
dc.contributor.authorMaia, Daniele C. G. [UNESP]
dc.contributor.authorLopes, Flavia C. M. [UNESP]
dc.contributor.authorSantos, Rubens [UNESP]
dc.contributor.authorPavan, Fernando R. [UNESP]
dc.contributor.authorFujimura Leite, Clarice Q. [UNESP]
dc.contributor.authorCalvo, Tamara Regina [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorCarlos, Iracilda Z. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:23:53Z
dc.date.available2014-05-20T13:23:53Z
dc.date.issued2010-08-01
dc.description.abstractMycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The antimycobacterial activity and the innate immune response of methanol (METH) and dichloromethane (DCM) extracts of Indigofera suffruticosa Miller (Fabaceae) were evaluated. We observed that the minimum inhibitory concentrations (MICs) for METH and DCM extracts were 125 and 1000 mu g/mL, respectively. However, they were able to induce the innate immune response through the production of high levels of NO and TNF-alpha (p < 0.001) by peritoneal exudate cells (PECs). These results suggest that I. suffruticosa extracts may have an important immunological role in the control of TB once macrophage activity is induced by them.en
dc.description.affiliationUNESP, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUNESP, Dept Quim Organ, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Anal Clin, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Ciencias Biol, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Quim Organ, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent878-882
dc.identifierhttp://dx.doi.org/10.3109/13880200903303471
dc.identifier.citationPharmaceutical Biology. Philadelphia: Taylor & Francis Inc, v. 48, n. 8, p. 878-882, 2010.
dc.identifier.doi10.3109/13880200903303471
dc.identifier.issn1388-0209
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/7285
dc.identifier.wosWOS:000281304800006
dc.language.isoeng
dc.publisherTaylor & Francis Inc
dc.relation.ispartofPharmaceutical Biology
dc.relation.ispartofjcr1.918
dc.relation.ispartofsjr0,563
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAntimycobacterial activityen
dc.subjectIndigofera suffruticosaen
dc.subjectinnate immune responseen
dc.titleAntimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune systemen
dc.typeArtigo
dcterms.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dcterms.rightsHolderTaylor & Francis Inc
unesp.author.orcid0000-0003-3032-2556[9]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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