Different responses to doxorubicin-induced chromosome aberrations in Brazilian deer species

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dc.contributor.authorVargas-Munar, D. S. F. [UNESP]
dc.contributor.authorSarria-Perea, J. A. [UNESP]
dc.contributor.authorDuarte, J. M. B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:34:21Z
dc.date.available2014-05-20T15:34:21Z
dc.date.issued2010-01-01
dc.description.abstractThe tendency toward chromosome fragility is one of the theories that may explain chromosome variation in brocket deer species (genus Mazama). We tested doxorubicin as an inducer of chromosome aberrations in lymphocytes of three brocket deer species, Mazama gouazoubira, M. americana and M. nana, compared to the marsh deer, Blastocerus dichotomus. Doxorubicin, at a concentration of 0.25 mu g/mL, induced chromosome aberrations and fragile sites in all four species; the highest frequencies were seen in M. gouazoubira; they were lowest in B. dichotomus and intermediate in M. americana and M. nana. These results were expected based on previous karyotypic studies, but they failed to explain the higher sensitivity seen in M. gouazoubira. This may be because not all the aberrations and fragile sites are related to chromosome evolution in brocket deer; other factors, such as environmental influences, may be involved in chromosome fragility.en
dc.description.affiliationUniv Estadual Paulista, Dept Genet & Melhoramento Anim, Jaboticabal, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Genet & Melhoramento Anim, Jaboticabal, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFCAV/UNESP
dc.format.extent1545-1549
dc.identifierhttp://dx.doi.org/10.4238/vol9-3gmr822
dc.identifier.citationGenetics and Molecular Research. Ribeirao Preto: Funpec-editora, v. 9, n. 3, p. 1545-1549, 2010.
dc.identifier.doi10.4238/vol9-3gmr822
dc.identifier.fileWOS000282756600008.pdf
dc.identifier.issn1676-5680
dc.identifier.urihttp://hdl.handle.net/11449/42518
dc.identifier.wosWOS:000282756600008
dc.language.isoeng
dc.publisherFunpec-editora
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBlastocerusen
dc.subjectCervidaeen
dc.subjectChromosome evolutionen
dc.subjectChromosome fragilityen
dc.subjectMazamaen
dc.titleDifferent responses to doxorubicin-induced chromosome aberrations in Brazilian deer speciesen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/2
dcterms.rightsHolderFunpec-editora
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt

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