Porosity measurement of solid pharmaceutical dosage forms by gamma-ray transmission

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dc.contributor.authorde Oliveira, Jose Martins
dc.contributor.authorAndreo Filho, Newton
dc.contributor.authorChaud, Marco Vinicius
dc.contributor.authorAngiolucci, Tatiana
dc.contributor.authorAranha, Norberto
dc.contributor.authorGermano Martins, Antonio Cesar [UNESP]
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:31:36Z
dc.date.available2014-05-20T15:31:36Z
dc.date.issued2010-12-01
dc.description.abstractThe aim of the present work is the determination of porosity in tablets by using the gamma-ray transmission technique Tablet dissolution depends on some inherent characteristics of the manufacturing process, such as compression force, tablet volume, density and porosity, nature of excipients, preparation methods and its physical-chemical properties Porosity is a measure of empty spaces in a material and can be determined by various techniques In this paper, we propose the use of a gamma-lay transmission technique to obtain the porosity of experimental formulation of tablets. The results of porosity were compared with those obtained by using conventional methodology (density and mercury intrusion) The experimental setup for gamma-ray transmission consists of a gamma-ray source of (241)Am (photons of 59.6 keV and an activity of 3.7 x 10(9) Bq), an Nal(Tl) scintillation detector, collimators and a standard gamma-ray spectrometry electronics. Our results suggest that the gamma-ray transmission technique is a powerful tool for non-destructive porosity quantification of solid pharmaceutical forms and presents smaller errors than those obtained with conventional methodologies (C) 2010 Elsevier Ltd. All rights reserveden
dc.description.affiliationUniv Sorocaba, UNISO, BR-18035430 Sorocaba, SP, Brazil
dc.description.affiliationUniv Estadual Paulista, UNESP, GAGI, BR-18087180 Sorocaba, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, GAGI, BR-18087180 Sorocaba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent2223-2228
dc.identifierhttp://dx.doi.org/10.1016/j.apradiso.2010.06.015
dc.identifier.citationApplied Radiation and Isotopes. Oxford: Pergamon-Elsevier B.V. Ltd, v. 68, n. 12, p. 2223-2228, 2010.
dc.identifier.doi10.1016/j.apradiso.2010.06.015
dc.identifier.issn0969-8043
dc.identifier.urihttp://hdl.handle.net/11449/40698
dc.identifier.wosWOS:000283384400018
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofApplied Radiation and Isotopes
dc.relation.ispartofjcr1.123
dc.relation.ispartofsjr0,528
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectPorosityen
dc.subjectDensityen
dc.subjectGamma-ray transmissionen
dc.subjectAttenuationen
dc.subjectTableten
dc.titlePorosity measurement of solid pharmaceutical dosage forms by gamma-ray transmissionen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes9625195382275378[6]
unesp.author.orcid0000-0002-7683-8729[6]

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