Influence of Parstatin on Experimental Periodontal Disease and Repair in Rats

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dc.contributor.authorSpolidório, Luis Carlos [UNESP]
dc.contributor.authorRamalho Lucas, Pablo Dallari [UNESP]
dc.contributor.authorSteffens, Joao Paulo [UNESP]
dc.contributor.authorBueno da Silva, Henrique Aparecido
dc.contributor.authorEuzebio Alves, Vanessa Tubero
dc.contributor.authorPalomari Spolidorio, Denise M. [UNESP]
dc.contributor.authorHolzhausen, Marinella
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2015-03-18T15:56:10Z
dc.date.available2015-03-18T15:56:10Z
dc.date.issued2014-09-01
dc.description.abstractBackground: Parstatin is a 41-amino acid peptide, formed by proteolytic cleavage on activation of the protease activated receptor-1, with antiangiogenic properties. The purpose of this study is to evaluate the influence of synthetic parstatin on experimental periodontal disease and repair in rats.Methods: Ligature-induced periodontitis was established in rats and the influence of parstatin administration was assessed after 8 and 15 days for periodontal disease and 24 hours and 8 days after repair after ligature removal.Results: Parstatin administration significantly inhibited gingival myeloperoxidase activity, interleukin (IL)-1 beta, tumor necrosis factor-alpha, and IL-6 levels and led to suppression of macrophages and collagen degradation. At periodontal tissues under repair, parstatin increased the gingival levels of endostatin and decreased vascular endothelial growth factor expression and blood vessel number but did not influence histologic healing. In addition, the tomographic linear bone loss was significantly reduced at 15 days of periodontitis when the rats were treated with parstatin compared to their respective phosphate-buffered saline-treated controls.Conclusions: Parstatin suppresses the periodontal tissue breakdown followed by experimental periodontitis in rats and did not impair periodontal tissue repair, despite its antiangiogenic effect. Parstatin may represent a novel approach to modulate host response in chronic periodontal disease.en
dc.description.affiliationState Univ Sao Paulo, Dept Physiol & Pathol, Dent Sch Araraquara, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Sch Dent, Dept Stomatol, Div Periodont, Sao Paulo, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Dept Physiol & Pathol, Dent Sch Araraquara, Sao Paulo, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipResearch and Technology National Council
dc.description.sponsorshipCoordination for the Improvement of Upper Education Personnel
dc.description.sponsorshipIdFAPESP: 10/10715-9
dc.description.sponsorshipIdFAPESP: 10/16605-0
dc.format.extent1266-1274
dc.identifierhttp://dx.doi.org/10.1902/jop.2014.130619
dc.identifier.citationJournal Of Periodontology. Chicago: Amer Acad Periodontology, v. 85, n. 9, p. 1266-1274, 2014.
dc.identifier.doi10.1902/jop.2014.130619
dc.identifier.issn0022-3492
dc.identifier.lattes2640929291808415
dc.identifier.urihttp://hdl.handle.net/11449/117449
dc.identifier.wosWOS:000341580700019
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal Of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectInflammationen
dc.subjectneovascularization, physiologicen
dc.subjectPAR-1 receptor (1-41), humanen
dc.subjectperiodontal diseasesen
dc.subjectratsen
dc.subjectwound healingen
dc.titleInfluence of Parstatin on Experimental Periodontal Disease and Repair in Ratsen
dc.typeArtigo
dcterms.rightsHolderAmer Acad Periodontology
unesp.author.lattes2640929291808415
unesp.author.orcid0000-0003-2376-1024[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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