Quality standardization of herbal medicines of Spondias dulcis Parkinson using analytical and microbiological analysis

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dc.contributor.authorAlencar Fernandes, Felipe Hugo [UNESP]
dc.contributor.authorBoylan, Fabio
dc.contributor.authorNunes Salgado, Herida Regina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUNIFACISA Ctr Univ
dc.contributor.institutionTrinity Coll Dublin
dc.date.accessioned2019-10-05T04:11:06Z
dc.date.available2019-10-05T04:11:06Z
dc.date.issued2018-12-01
dc.description.abstractThe quality control is vital for the safety and efficacy of herbal medicines. However, the quality of standardization is most difficult because the studies do not cover this step. The objective of this study was quality standardization of herbal drugs of Spondias dulcis Parkinson. The leaves were dried and ground to a powder. The plant drug was evaluated by parameters of mean particle size (417.85m), apparent density (0.37 +/- 0.01gmL(-1)), moisture content (7.96 +/- 0.35%), loss on drying (7.33 +/- 0.09%), pH (3.90 +/- 0.01), total ash (12.66 +/- 0.23%), acid insoluble ash (3.22 +/- 0.20%) and aqueous extractives (24.00 +/- 3.28%). Phytochemical screening revealed the presence of flavonoids and tannins. Microbiological analysis presented a total count within the recommended limits and the absence of pathogenic microorganisms. The infrared spectroscopy (FTIR) and thermal analysis (TG/DTA) showed that physical and chemical processes occurred. The FTIR fingerprint has been characterized by characteristic peaks. The TG curves present six steps, and DTA curve presents three events. The results provide the scientific data for the proper identification and establishment of standards for future investigations and applications.en
dc.description.affiliationSao Paulo State Univ, Sch Pharmaceut Sci, Route Araraquara Jau Km1,Campus Ville, BR-14800903 Araraquara, SP, Brazil
dc.description.affiliationUNIFACISA Ctr Univ, Fac Ciencias Med, Campina Grande, PB, Brazil
dc.description.affiliationTrinity Coll Dublin, Trinity Biomed Sci Inst, Sch Pharm & Pharmaceut Sci, Dublin, Ireland
dc.description.affiliationUnespSao Paulo State Univ, Sch Pharmaceut Sci, Route Araraquara Jau Km1,Campus Ville, BR-14800903 Araraquara, SP, Brazil
dc.description.sponsorshipPADC-FCFAr Unesp
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1923-1928
dc.identifierhttp://dx.doi.org/10.1007/s10973-018-7486-2
dc.identifier.citationJournal Of Thermal Analysis And Calorimetry. Dordrecht: Springer, v. 134, n. 3, p. 1923-1928, 2018.
dc.identifier.doi10.1007/s10973-018-7486-2
dc.identifier.issn1388-6150
dc.identifier.urihttp://hdl.handle.net/11449/186520
dc.identifier.wosWOS:000452552900049
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofJournal Of Thermal Analysis And Calorimetry
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectHerbal drugs
dc.subjectThermoanalytical characterization
dc.subjectPhysicochemical characterization
dc.titleQuality standardization of herbal medicines of Spondias dulcis Parkinson using analytical and microbiological analysisen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

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Artigos - Fármacos e Medicamentos - FCFAR