Development and validation of a method for the determination of folic acid in different pharmaceutical formulations using derivative spectrophotometry

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dc.contributor.authorRibeiro, Marcos Vinícius de Moura [UNESP]
dc.contributor.authorMelo, Ingrid da Silva
dc.contributor.authorLopes, Francisco das Chagas da Costa
dc.contributor.authorMoita, Graziella Ciaramella
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionFederal University of Piauí
dc.date.accessioned2018-12-11T16:46:06Z
dc.date.available2018-12-11T16:46:06Z
dc.date.issued2016-10-01
dc.description.abstractFolic acid is a B complex water-soluble vitamin that is essential to humans, and its deficiency can cause problems including congenital malformations in the fetus as well as heart disease. Most countries affected by diseases associated with a lack of folic acid now supplement foods with the vitamin. There is therefore a need for the development of new analytical procedures able to determine folic acid present in different matrices. This work describes the development of zero order and first order derivative spectrophotometric methods for the determination of folic acid in different pharmaceutical formulations, using 0.1 mol L-1NaOH as solvent. The methods are shown to be simple, selective, and robust. Good linearity was achieved, with correction coefficients ≥0.9996 and limits of detection and quantification ranging from 0.64 to 0.75 and from 1.80 to 2.85 mg L-1, respectively. Recoveries of 98-104% were obtained in accuracy tests, and precision (as RSD) was between 0.2 and 4.8%. The methods can be used in routine analyses for quality control purposes, offering an alternative to the procedures already reported in the literature.en
dc.description.affiliationInstitute of Chemistry São Paulo State University “Júlio de Mesquita Filho” UNESP
dc.description.affiliationDepartment of Chemistry Natural Science Center Federal University of Piauí
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University “Júlio de Mesquita Filho” UNESP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipUniversidade Federal do Piauí
dc.format.extent741-750
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502016000400019
dc.identifier.citationBrazilian Journal of Pharmaceutical Sciences, v. 52, n. 4, p. 741-750, 2016.
dc.identifier.doi10.1590/S1984-82502016000400019
dc.identifier.fileS1984-82502016000400741.pdf
dc.identifier.issn2175-9790
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502016000400741
dc.identifier.scopus2-s2.0-85013675356
dc.identifier.urihttp://hdl.handle.net/11449/169486
dc.language.isoeng
dc.relation.ispartofBrazilian Journal of Pharmaceutical Sciences
dc.relation.ispartofsjr0,214
dc.relation.ispartofsjr0,214
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectFolic acid/formulations/derivative spectrophotometry
dc.subjectFolic acid/pharmaceutical formulations
dc.subjectFolic acid/pharmaceutical formulations/validation method
dc.titleDevelopment and validation of a method for the determination of folic acid in different pharmaceutical formulations using derivative spectrophotometryen
dc.typeArtigo

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