Can genetic factors compromise the success of dental implants? A systematic review and meta-analysis

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dc.contributor.authorSantiago Junior, Joel Ferreira
dc.contributor.authorBiguetti, Claudia Cristina [UNESP]
dc.contributor.authorMatsumoto, Mariza Akemi [UNESP]
dc.contributor.authorKudo, Guilherme Abu Halawa
dc.contributor.authorda Silva, Raquel Barroso Parra [UNESP]
dc.contributor.authorSaraiva, Patrícia Pinto
dc.contributor.authorFakhouri, Walid D.
dc.contributor.institutionUSC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Texas Health Science Center at Houston
dc.contributor.institutionUniversity of Texas Health Science Center
dc.date.accessioned2018-12-11T16:55:23Z
dc.date.available2018-12-11T16:55:23Z
dc.date.issued2018-09-06
dc.description.abstractDental implants provide a predictable treatment option for partial and complete edentulism via the placement of a fixed permanent artificial root to support prosthetic dental crowns. Despite the high survival rates, long-term dental implant failures are still reported, leading to implant removals and additional financial and health burdens. While extrinsic factors that improve the success rate of implants have been well explored, the impact of genetic factors on this matter is poorly understood. A systematic review and meta-analysis study was conducted to determine whether genetic factors contribute to an increased risk of dental implant failures. A comprehensive search for peer-reviewed articles on dental implants and genetic factors was performed using various literature database libraries. The study design was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, and the obtained records were registered in the International Prospective Register of Systematic Reviews (PROSPERO) database. According to the exclusion/inclusion criteria, 13 studies were eligible for this study out of 809 articles. The meta-analysis of the combined association studies of DNA variations and dental implants did not indicate an increased risk for implant failure due to DNA variations in IL-1B, IL-10 and TNF-α. This study emphasizes the need for larger randomized controlled clinical trials to inform clinicians and patients about the role of genetic factors on dental implant survival and the success rate in healthy and compromised patients.en
dc.description.affiliationPró-Reitoria de Pesquisa e Pós-graduação (PRPPG) Universidade do Sagrado Coração USC, 10-50 Irmã Arminda, Jardim Brasil
dc.description.affiliationDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.description.affiliationCenter for Craniofacial Research Department of Diagnostic and Biomedical Sciences School of Dentistry University of Texas Health Science Center at Houston
dc.description.affiliationDepartment of Pediatrics McGovern Medical School University of Texas Health Science Center
dc.description.affiliationUnespDepartment of Basic Sciences São Paulo State University (Unesp) School of Dentistry
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipIdFAPESP: 2015/20827-2
dc.description.sponsorshipIdFAPESP: 2017/13276-5
dc.description.sponsorshipIdNational Institutes of Health: R15GM122030-01
dc.identifierhttp://dx.doi.org/10.3390/genes9090444
dc.identifier.citationGenes, v. 9, n. 9, 2018.
dc.identifier.doi10.3390/genes9090444
dc.identifier.file2-s2.0-85053259763.pdf
dc.identifier.issn2073-4425
dc.identifier.lattes8621510886887389
dc.identifier.scopus2-s2.0-85053259763
dc.identifier.urihttp://hdl.handle.net/11449/171451
dc.language.isoeng
dc.relation.ispartofGenes
dc.relation.ispartofsjr1,820
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectBone quality
dc.subjectBone regeneration
dc.subjectDental implants
dc.subjectGenetic factors
dc.subjectSurvival rate
dc.titleCan genetic factors compromise the success of dental implants? A systematic review and meta-analysisen
dc.typeResenha
unesp.author.lattes8621510886887389

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