Assessing genetic architecture and signatures of selection of dual purpose Gir cattle populations using genomic information

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dc.contributor.authorMaiorano, Amanda Marchi [UNESP]
dc.contributor.authorLourenco, Daniela Lino
dc.contributor.authorTsuruta, Shogo
dc.contributor.authorToro Ospina, Alejandra Maria [UNESP]
dc.contributor.authorStafuzza, Nedenia Bonvino [UNESP]
dc.contributor.authorMasuda, Yutaka
dc.contributor.authorEugenio, Anibal
dc.contributor.authorSantos Goncalves Cyrillo, Joslaine Noely dos
dc.contributor.authorCuri, Rogerio Abdallah [UNESP]
dc.contributor.authorVasconcelos Silva, Josineudson Augusto I. I. de [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Georgia
dc.contributor.institutionInst Zootecnia
dc.date.accessioned2018-11-29T23:35:05Z
dc.date.available2018-11-29T23:35:05Z
dc.date.issued2018-08-02
dc.description.abstractGir is one of the main cattle breeds raised in tropical South American countries. Strong artificial selection through its domestication resulted in increased genetic differentiation among the countries in recent years. Over the years, genomic studies in Gir have become more common. However, studies of population structure and signatures of selection in divergent Gir populations are scarce and need more attention to better understand genetic differentiation, gene flow, and genetic distance. Genotypes of 173 animals selected for growth traits and 273 animals selected for milk production were used in this study. Clear genetic differentiation between beef and dairy populations was observed. Different criteria led to genetic divergence and genetic differences in allele frequencies between the two populations. Gene segregation in each population was forced by artificial selection, promoting isolation, and increasing genetic variation between them. Results showed evidence of selective forces in different regions of the genome. A total of 282 genes were detected under selection in the test population based on the fixation index (Fst), integrated haplotype score (iHS), and cross-population extend haplotype homozygosity (XP-EHH) approaches. The QTL mapping identified 35 genes associated with reproduction, milk composition, growth, meat and carcass, health, or body conformation traits. The investigation of genes and pathways showed that quantitative traits associated to fertility, milk production, beef quality, and growth were involved in the process of differentiation of these populations. These results would support further investigations of population structure and differentiation in the Gir breed.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, Brazil
dc.description.affiliationUniv Georgia, Anim & Dairy Sci, Anim Breeding & Genet, Athens, GA 30602 USA
dc.description.affiliationInst Zootecnia, Sao Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Agr & Vet, Sao Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecnia, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 2015/06686-7
dc.description.sponsorshipIdCNPq: 142373/2015-0
dc.description.sponsorshipIdCAPES: 88881.131671/2016-01
dc.format.extent24
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0200694
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 13, n. 8, 24 p., 2018.
dc.identifier.doi10.1371/journal.pone.0200694
dc.identifier.fileWOS000440778600016.pdf
dc.identifier.issn1932-6203
dc.identifier.lattes3514713413919126
dc.identifier.orcid0000-0001-6289-0406
dc.identifier.urihttp://hdl.handle.net/11449/166265
dc.identifier.wosWOS:000440778600016
dc.language.isoeng
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleAssessing genetic architecture and signatures of selection of dual purpose Gir cattle populations using genomic informationen
dc.typeArtigo
dcterms.rightsHolderPublic Library Science
unesp.author.lattes3514713413919126[9]
unesp.author.orcid0000-0001-6289-0406[9]

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