Abarema cochliacarpos: Gastroprotective and ulcer-healing activities

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dc.contributor.authorda Silva, Maria Silene
dc.contributor.authorAlves de Almeida, Ana Cristina
dc.contributor.authorde Faria, Felipe Meira
dc.contributor.authorLuiz-Ferreira, Anderson
dc.contributor.authorda Silva, Marcelo Aparecido [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorPellizzon, Claudia Helena [UNESP]
dc.contributor.authorMonteiro Souza Brito, Alba Regina
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:52:09Z
dc.date.available2014-05-20T13:52:09Z
dc.date.issued2010-10-28
dc.description.abstractEthnopharmacological relevance: Abarema cochliacarpos (Gomes) Barneby & Grimes (Mimosaceae) is a species - in folk medicine of Lagarto city, Sergipe state, northeastern Brazil - reputed to heal gastric ulcer and gastritis.Aim of the study: Chloroform (CE) and methanolic (ME) extracts as well as ethyl acetate fraction (AF), butanolic fraction (AC) and aqueous fraction (AQF) of the methanolic extract of Abarema cochliacarpos bark were evaluated against acute gastric ulcer. The AC fraction was selected to assess its activity in ulcer healing and its gastroprotective effects via mucus and gastric secretion.Material and methods: The gastroprotective action of CE and ME extracts and the fractions of the latter were evaluated in a rodent experimental model. The action mechanisms, involvements of the antisecretory action and mucus production, toxicological and healing activity of the AC (150 mg/kg, p.o.) were evaluated. We also used histological analysis (HE and PAS) and immunohistochemical (PCNA, COX-2, VEGF and HSP-70) assays to evaluate the effects of Abarema cochliacarpos.Results: CE (200 and 400 mg/kg, p.o.) and ME (100, 200 and 400 mg/kg, p.o.) extracts were able to protect gastric mucosa against absolute ethanol. Respective inhibitions produced were: 65.31% and 83.80% by the first; 91.69%, 96.75% and 99.80% by the second; and 74.24% by the AC fraction. Antisecretory and mucus production effects were exhibited by the AC fraction, which also accelerated the healing of ulcerated gastric mucosa by stimulating proliferation factors (PCNA) and induced healing factors including COX-2, VEGF and HSP-70.Conclusion: All these results suggest that Abarema cochliacarpos (Comes) Barneby & Grimes presents gastroprotective effects and wound-healing properties. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Estadual Campinas, Dept Anat Biol Celular & Fisiol & Biofis IB, UNICAMP, BR-13083970 Campinas, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Quim Organ, Inst Quim, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Dept Morfol, Inst Biociencias, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Quim Organ, Inst Quim, UNESP, BR-14801970 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Dept Morfol, Inst Biociencias, UNESP, BR-18618000 Botucatu, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipInstituto Federal de Educacao
dc.description.sponsorshipCiência e Tecnologia de Sergipe (IFS, Brazil)
dc.description.sponsorshipUniversidade Estadual de Alagoas (UNEAL, Brazil)
dc.format.extent134-142
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2010.08.001
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 132, n. 1, p. 134-142, 2010.
dc.identifier.doi10.1016/j.jep.2010.08.001
dc.identifier.issn0378-8741
dc.identifier.lattes0019393779801069
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.orcid0000-0002-4494-4180
dc.identifier.urihttp://hdl.handle.net/11449/18632
dc.identifier.wosWOS:000284442100015
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Ethnopharmacology
dc.relation.ispartofjcr3.115
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAbarema cochliacarposen
dc.subjectMimosaceaeen
dc.subjectHealing ulceren
dc.subjectPolyphenolsen
dc.subjectPCNAen
dc.subjectCOX-2en
dc.subjectVEGFen
dc.subjectHSP-70en
dc.titleAbarema cochliacarpos: Gastroprotective and ulcer-healing activitiesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0019393779801069[7]
unesp.author.orcid0000-0002-7875-0691[3]
unesp.author.orcid0000-0002-4494-4180[7]
unesp.author.orcid0000-0003-0940-2252[4]
unesp.author.orcid0000-0002-8509-8670[2]
unesp.author.orcid0000-0003-3032-2556[6]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Química, Araraquarapt

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