Effect of erythrosine- and LED-mediated photodynamic therapy on buccal candidiasis infection of immunosuppressed mice and Candida albicans adherence to buccal epithelial cells

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dc.contributor.authorBorges Pereira Costa, Anna Carolina [UNESP]
dc.contributor.authorCampos Rasteiro, Vanessa Maria [UNESP]
dc.contributor.authorHashimoto, Emily Setsuko Halter da Silva [UNESP]
dc.contributor.authorAraujo, Cassia Fernandes [UNESP]
dc.contributor.authorPereira, Cristiane Aparecida [UNESP]
dc.contributor.authorJunqueira, Juliana Campos [UNESP]
dc.contributor.authorCardoso Jorge, Antonio Olavo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:04:48Z
dc.date.available2014-05-20T14:04:48Z
dc.date.issued2012-07-01
dc.description.abstractObjective. This study evaluated the effects of photodynamic therapy (PDT) on buccal candidiasis in mice and on the adherence of yeast to buccal epithelial cells (BECs) in vitro.Study Design. A total of 56 immunosuppressed mice with buccal candidiasis were subjected to PDT, consisting of treatment with erythrosine (400 mu mol/L) followed by exposure to a green LED (14.34 J cm(-2)). After treatment, the yeasts recovered from the mice were quantified (CFU/mL) and analyzed for the effects of PDT on their adherence to BECs. The data were analyzed using ANOVA, the Tukey test, Kruskal-Wallis test and Student t test.Results. PDT significantly reduced the amount of yeast present in the lesions by 0.73 log(10) (P = .018) and reduced C. albicans adherence to BECs by 35% without damaging adjacent tissues (P = .045).Conclusions. Photodynamic therapy exhibited antifungal effects against C. albicans biofilms formed in vivo and reduced the capacity of C. albicans to adhere to BECs in vitro. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:67-74)en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Biosci & Oral Diag, Sch Dent Sao Jose dos Campos, Sao Jose Dos Campos, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 09/52048-1
dc.description.sponsorshipIdFAPESP: 10/18753-7
dc.description.sponsorshipIdFAPESP: 09/12005-1
dc.description.sponsorshipIdFAPESP: 10/01988-1
dc.description.sponsorshipIdFAPESP: 10/00879-4
dc.format.extent67-74
dc.identifierhttp://dx.doi.org/10.1016/j.oooo.2012.02.002
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology. New York: Elsevier B.V., v. 114, n. 1, p. 67-74, 2012.
dc.identifier.doi10.1016/j.oooo.2012.02.002
dc.identifier.fileWOS000306286300025.pdf
dc.identifier.issn2212-4403
dc.identifier.lattes0322020541055900
dc.identifier.lattes0053567153623569
dc.identifier.urihttp://hdl.handle.net/11449/22719
dc.identifier.wosWOS:000306286300025
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOral Surgery Oral Medicine Oral Pathology Oral Radiology
dc.relation.ispartofjcr1.718
dc.relation.ispartofsjr0,720
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEffect of erythrosine- and LED-mediated photodynamic therapy on buccal candidiasis infection of immunosuppressed mice and Candida albicans adherence to buccal epithelial cellsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes0322020541055900
unesp.author.lattes0053567153623569[7]
unesp.author.orcid0000-0002-1747-6158[7]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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Artigos - Biociências e Diagnóstico Bucal - ICT