Nalbufina e morfina intracameral em cães

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dc.contributor.advisorOliva, Valéria Nobre Leal de Souza [UNESP]
dc.contributor.authorFerreira, Joana Zafalon [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2016-09-27T13:40:02Z
dc.date.available2016-09-27T13:40:02Z
dc.date.issued2015-01-23
dc.description.abstractIntracameral injection is used for treatment and anesthesia of the eye bulb and opioids are known to provide analgesia through this route. The aim of the study was to evaluate the viability and efficacy of intracameral nalbuphine and morphine in dogs. Seven beagle dogs were randomly included in the groups of intracameral nalbuphine (GNIC), intracameral morphine (GMIC), intravenous nalbuphine (GNIV) and intravenous morphine (GMIV) injection of either opioid. Variables were heart rate, respiratory rate, systolic arterial pressure, subjective pain scale, Schirmer's test, pupillary diameter, intraocular pressure, fluorescein test, corneal touch threshold, number and type of local or systemic complications and duration of effect on the cornea. Time point comprised baseline (T0) and measurements every 30 minutes after drugs administration up to 240 minutes. Parametric variables were analyzed through ANOVA for repeated measures and Dunnett's test. Ordinal data were compared through Friedman's test, followed by Dunn's test. Analyses were performed by SAS and were considered significant when P<0.05. Analgesia lasted significantly longer in GNIC, whereas GMIC, GNIV and GMIV did not differ between one another. There was a significant decrease in the IOP at T30 in all groups when compared to baseline measures. As for complications, no difference was found between groups. Therefore, both nalbuphine and morphine can be used for intracameral analgesia, and nalbuphine is the preferred option due to the prolonged analgesia.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/02162-4
dc.format.extent94 f.
dc.identifier.aleph000870463
dc.identifier.capes33004021075P8
dc.identifier.citationFERREIRA, Joana Zafalon. Nalbufina e morfina intracameral em cães. 2015. 94 f. Tese (Doutorado) - Universidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina Veterinária, 2015.
dc.identifier.filehttp://www.athena.biblioteca.unesp.br/exlibris/bd/cathedra/14-09-2016/000870463.pdf
dc.identifier.lattes0450092066822376
dc.identifier.urihttp://hdl.handle.net/11449/144069
dc.language.isopor
dc.publisherUniversidade Estadual Paulista (Unesp)
dc.rights.accessRightsAcesso aberto
dc.sourceAleph
dc.subjectAnalgesiapt
dc.subjectAnestesia veterinariapt
dc.subjectOpióidespt
dc.subjectCãespt
dc.subjectMorfinapt
dc.subjectOftalmologia veterinariapt
dc.subjectAnterior chamberpt
dc.titleNalbufina e morfina intracameral em cãespt
dc.typeTese de doutorado
unesp.author.lattes0450092066822376
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária, Araçatubapt
unesp.graduateProgramCiência Animal - FMVApt
unesp.knowledgeAreaFisiopatologia Médica e Cirúrgicapt
unesp.researchAreaFisiopatologia Médica e Cirúrgica de pequenos animaispt

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