End-systolic pressure-diameter relation of the left ventricle during transient and sustained elevations of blood pressure

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dc.contributor.authorBregagnollo, Edson Antônio [UNESP]
dc.contributor.authorOkoshi, Katashi [UNESP]
dc.contributor.authorMatsubara, Beatriz Bojikian [UNESP]
dc.contributor.authorTucci, Paulo José Ferreira [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T15:07:13Z
dc.date.available2014-05-20T15:07:13Z
dc.date.issued2000-07-01
dc.description.abstractOBJECTIVE: To assess the effect of transient and sustained variations in cardiac load on the values of the end-systolic pressure-diameter relation (ESPDR) of the left ventricle. METHODS: We studied 13 dogs under general anesthesia and autonomic blockade. Variations of cardiac loads were done by elevation of blood pressure by mechanical constriction of the aorta. Two protocols were used in each animal: gradual peaking and decreasing pressure variation, the transient arterial hypertension protocol (TAH), and a quick and 10 min sustained elevation, the sustained arterial hypertension protocol(SAH). Then, we compared the ESDR in these two situations. RESULTS: Acute elevation of arterial pressure, being it transitory or sustained, did not alter the heart frequency and increased similarly the preload and after load. However, they acted differently in end systolic pressure-diameter relation. It was greater in the SAH than TAH protocol, 21.0±7.3mmHg/mm vs. 9.2±1.2mmHg/mm (p<0.05). CONCLUSION: The left ventricular ESPDR values determined during sustained pressure elevations were higher than those found during transient pressure elevations. The time-dependent activation of myocardial contractility associated with the Frank-Starling mechanism is the major factor in inotropic stimulation during sustained elevations of blood pressure, determining an increase in the ESPDR values.en
dc.description.affiliationUniversidade Estadual de São Paulo Faculdade de Medicina de Botucatu
dc.format.extent26-32
dc.identifierhttp://dx.doi.org/10.1590/S0066-782X2000000700003
dc.identifier.citationArquivos Brasileiros de Cardiologia. Sociedade Brasileira de Cardiologia - SBC, v. 75, n. 1, p. 26-32, 2000.
dc.identifier.doi10.1590/S0066-782X2000000700003
dc.identifier.fileS0066-782X2000000700003.pdf
dc.identifier.issn0066-782X
dc.identifier.lattes1590971576309420
dc.identifier.lattes6990977122340795
dc.identifier.scieloS0066-782X2000000700003
dc.identifier.scopus2-s2.0-0041494278
dc.identifier.urihttp://hdl.handle.net/11449/26421
dc.language.isoeng
dc.publisherSociedade Brasileira de Cardiologia (SBC)
dc.relation.ispartofArquivos Brasileiros de Cardiologia
dc.relation.ispartofjcr1.318
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectend-systolic pressure-diameter relationsen
dc.subjectcardiac inotropismen
dc.subjectarterial hypertensionen
dc.titleEnd-systolic pressure-diameter relation of the left ventricle during transient and sustained elevations of blood pressureen
dc.title.alternativeA elastância sistólica final do ventrículo esquerdo determinada durante elevações transitórias e elevações sustentadas da pressão arterialpt
dc.typeArtigo
unesp.author.lattes1590971576309420
unesp.author.lattes6990977122340795
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Clínica Médica - FMB