Lip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experience

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dc.contributor.authorBiasoli, Éder Ricardo [UNESP]
dc.contributor.authorValente, Vitor Bonetti [UNESP]
dc.contributor.authorMantovan, Bruna [UNESP]
dc.contributor.authorCollado, Francisco Urbano [UNESP]
dc.contributor.authorNeto, Sebastião Conrado [UNESP]
dc.contributor.authorSundefeld, Maria Lúcia Marçal Mazza [UNESP]
dc.contributor.authorMiyahara, Glauco Issamu [UNESP]
dc.contributor.authorBernabé, Daniel Galera [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:33Z
dc.date.available2018-12-11T17:01:33Z
dc.date.issued2016-07-01
dc.description.abstractPurpose There are few clinical studies focusing on treatment outcomes of lip cancer. This study investigated the clinicopathologic variables of a large sample of patients with lip squamous cell carcinoma (LSCC) treated in a reference head and neck cancer center for the past 25 years and analyzed the influence of these variables on treatment outcomes. Materials and Methods This retrospective cohort study reviewed the clinical records of patients with LSCC. Epidemiologic data were age, gender, ethnicity, type of occupation, tobacco smoking, alcohol consumption, comorbid conditions, and family cancer history. Clinicopathologic features included the lip location of the tumor, TNM classification, clinical staging, histopathologic grade, surgical margin analysis, and treatment modality. Local recurrence, second primary tumor, and survival were the outcome variables. Statistical analysis was performed by χ2 test, Fisher exact test, and binary logistic regression analysis. Survival analysis was assessed through the Kaplan-Meier curve. Level of statistical significance was set at a P value less than.05 for all tests. Results In total, 144 patients with LSCC were studied. There were 117 men (81.25%) and 27 women (18.75%) with a mean age of 60.21 years. One hundred thirty-four patients (93.05%) were considered of white ethnicity, and in 57 cases (39.58%), the patients reported an occupation that was related to long-term solar exposure. Most cancers had initial clinical staging of 1 or 2 (84.02%). Microscopically, lesions were predominantly well (43.05%) and moderately (40.96%) differentiated tumors. Clinical staging was related to a specific higher survival rate (P =.0049). One hundred twelve cases (77.78%) underwent surgical treatment and only 6 patients (4.80%) had local recurrence, which was directly associated with compromised surgical margins (P =.0320). Conclusion A high success rate in LSCC treatment was observed in this study. Compromised surgical margin was associated with tumor recurrence and is a critical event in lip cancer treatment.en
dc.description.affiliationAdjunct Professor Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationMS Student in Stomatology Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationDental Surgeon Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationOncologist Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationHead and Neck Surgeon Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationOral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespAdjunct Professor Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespMS Student in Stomatology Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespDental Surgeon Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespOncologist Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespHead and Neck Surgeon Oral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespOral Oncology Center Araçatuba Dental School Univ Estadual Paulista (UNESP)
dc.format.extent1360-1367
dc.identifierhttp://dx.doi.org/10.1016/j.joms.2016.01.041
dc.identifier.citationJournal of Oral and Maxillofacial Surgery, v. 74, n. 7, p. 1360-1367, 2016.
dc.identifier.doi10.1016/j.joms.2016.01.041
dc.identifier.file2-s2.0-84959915850.pdf
dc.identifier.issn1531-5053
dc.identifier.issn0278-2391
dc.identifier.lattes3846891167083211
dc.identifier.orcid0000-0002-5326-2026
dc.identifier.scopus2-s2.0-84959915850
dc.identifier.urihttp://hdl.handle.net/11449/172640
dc.language.isoeng
dc.relation.ispartofJournal of Oral and Maxillofacial Surgery
dc.relation.ispartofsjr0,967
dc.relation.ispartofsjr0,967
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.titleLip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experienceen
dc.typeArtigo
unesp.author.lattes3846891167083211[1]
unesp.author.orcid0000-0002-5326-2026[1]

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Araçatuba - COB - Centro de Oncologia Bucal