Protective action of intravesical oxybutynin on bladder ultrastructure in rabbits with detrusor overactivity

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dc.contributor.authorYamamoto, Hamilto Akihissa [UNESP]
dc.contributor.authorKawano, Paulo Roberto [UNESP]
dc.contributor.authorBalasteghin, Karina Tuma [UNESP]
dc.contributor.authorPadovani, Carlos Roberto [UNESP]
dc.contributor.authorAmaro, João Luiz [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:38:49Z
dc.date.available2014-05-20T13:38:49Z
dc.date.issued2009-02-01
dc.description.abstractTo evaluate the protective effect of intravesical oxybutynin on the ultrastructure of rabbits with detrusor overactivity (DO). Seventeen North Folk male rabbits were distributed into three groups: GI (n = 5) used as control, GII (n = 5), and GIII (n = 5) with DO. One animal from GII and one from GIII were excluded because they did not develop DO. In GIII, the animals were treated with daily intravesical application of 0.5 mg/Kg of oxybutynin for 30 days. Bladder weight was significantly higher in animals from GII and GIII as compared to GI. After 30 days, cystometric study revealed that vesical capacity was significantly decreased in GII and GIII. Detrusor pressure was significantly higher in GII. Electron microscopy showed increase of intercellular space, cell junctions and caveolae areas asymmetries, mitochondria and cellular degeneration in GII, while in GIII, these alterations have improved after a 30-day treatment. Animals treated with intravesical oxybutynin presented ultrastructural aspect similar to normal.en
dc.description.affiliationFac Med Botucatu, Dept Urol, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Urol, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationUNESP, Dept Stat, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Urol, Sch Med, Botucatu, SP, Brazil
dc.description.affiliationUnespUNESP, Dept Stat, Sch Med, Botucatu, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 00/02593-0
dc.format.extent229-234
dc.identifierhttp://dx.doi.org/10.1007/s00192-008-0745-1
dc.identifier.citationInternational Urogynecology Journal. Artington: Springer London Ltd, v. 20, n. 2, p. 229-234, 2009.
dc.identifier.doi10.1007/s00192-008-0745-1
dc.identifier.issn0937-3462
dc.identifier.lattes9989857854355692
dc.identifier.orcid0000-0001-8411-5822
dc.identifier.urihttp://hdl.handle.net/11449/13465
dc.identifier.wosWOS:000262412800016
dc.language.isoeng
dc.publisherSpringer London Ltd
dc.relation.ispartofInternational Urogynecology Journal
dc.relation.ispartofjcr2.078
dc.relation.ispartofsjr0,932
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectIntravesical oxybutyninen
dc.subjectDetrusor overactivityen
dc.subjectRabbiten
dc.subjectUltrastructuralen
dc.titleProtective action of intravesical oxybutynin on bladder ultrastructure in rabbits with detrusor overactivityen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer London Ltd
unesp.author.lattes9989857854355692[2]
unesp.author.lattes8727897080522289[4]
unesp.author.orcid0000-0003-3745-0761[5]
unesp.author.orcid0000-0002-7719-9682[4]
unesp.author.orcid0000-0001-8411-5822[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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Artigos - Urologia - FMB