Genetic polymorphism of calcium-sensing receptor in women with breast cancer

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dc.contributor.authorCampos-Verdes, Larysse Maira
dc.contributor.authorSilva-Sampaio, Joao Paulo da
dc.contributor.authorCosta-Silva, Danylo Rafhael
dc.contributor.authorOliveira, Victor Alves de
dc.contributor.authorConde Junior, Airton Mendes
dc.contributor.authorSilva, Vladimir Costa
dc.contributor.authorAlencar, Airlane Pereira [UNESP]
dc.contributor.authorCampelo, Viriato
dc.contributor.authorLopes-Costa, Pedro Vitor
dc.contributor.authorGebrim, Luiz Henrique
dc.contributor.authorSilva, Benedito Borges da
dc.contributor.institutionUniv Fed Piaui
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-11-26T15:47:41Z
dc.date.available2018-11-26T15:47:41Z
dc.date.issued2018-03-01
dc.description.abstractBreast cancer is a disease of unknown etiology, whose major risk factors are genetic alterations. Polymorphism of the calcium-sensing receptor (CaSR) has been a focus of some recent studies, due to a probable association with breast cancer risk and tumor aggressiveness. A relationship between polymorphic rs17251221 variant of the CaSR gene, and allele G (considered a gain-of-function mutation) and breast cancer risk has been stressed, despite the paucity of studies found in the literature. The present study involved 137 women (69 women with breast cancer-case; and 68 controls without breast cancer) who had 3 ml of peripheral blood drawn for DNA study. Genomic DNA was extracted from leukocytes by genotyping technique with real-time polymerase chain reaction. The AG genotype (rs17251221) was present in 13 women (18.84%) from the case group and in 8 (11.76%) women from the control group (p = 0.3434), while the GG genotype (rs17251221) did not occur in any group. In contrast, no statistically significant difference was observed between the AG genotype of variant rs17251221 in premenopausal case and control women (p = 0.71). There was also no statistically significant difference between postmenopausal case and control patients (p = 0.6851). In the current study, CaSR gene polymorphism of SNP variant rs17251221 did not show any statistically significant association with breast cancer, in both premenopausal and postmenopausal women.en
dc.description.affiliationUniv Fed Piaui, Postgaduate Program Hlth & Sci, BR-64049550 Teresina, Brazil
dc.description.affiliationUniv Fed Piaui, Postgrad Program Northeast Network Biotechnol REN, BR-64049550 Teresina, Brazil
dc.description.affiliationUniv Fed Piaui, Natan Portella Hosp, Dept Mol Biol, BR-64001450 Teresina, Brazil
dc.description.affiliationState Univ Sao Paulo, Dept Stat, BR-03178200 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Mastol, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnespState Univ Sao Paulo, Dept Stat, BR-03178200 Sao Paulo, Brazil
dc.format.extent4
dc.identifierhttp://dx.doi.org/10.1007/s12032-018-1089-4
dc.identifier.citationMedical Oncology. Totowa: Humana Press Inc, v. 35, n. 3, 4 p., 2018.
dc.identifier.doi10.1007/s12032-018-1089-4
dc.identifier.fileWOS000427146700013.pdf
dc.identifier.issn1357-0560
dc.identifier.urihttp://hdl.handle.net/11449/160157
dc.identifier.wosWOS:000427146700013
dc.language.isoeng
dc.publisherHumana Press Inc
dc.relation.ispartofMedical Oncology
dc.relation.ispartofsjr0,757
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectBreast cancer
dc.subjectCalcium
dc.subjectCaSR polymorphism
dc.subjectMenopausal status
dc.subjectqPCR
dc.titleGenetic polymorphism of calcium-sensing receptor in women with breast canceren
dc.typeArtigo
dcterms.rightsHolderHumana Press Inc

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