Genomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis

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dc.contributor.authorRibeiro, D. A.
dc.contributor.authorSalvadori, Daisy Maria Favero [UNESP]
dc.contributor.authorda Silva, R. N.
dc.contributor.authorDarros, B. R.
dc.contributor.authorMarques, MEA
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:37:07Z
dc.date.available2014-05-20T13:37:07Z
dc.date.issued2004-10-01
dc.description.abstract4-Nitroquinotine 1-oxide (4NQO)-induced rat tongue carcinogenesis is a useful model for studying oral squamous cell carcinoma. The aim of this study was to investigate the level of DNA damage induced by 4NQO in oral mucosa cells by the single cell get (comet) assay. Mate Wistar rats were distributed into three groups of 10 animals each and treated with 50 ppm 4NQO solution by drinking water for 4, 12 or 20 weeks. Ten animals were used as negative control. Statistically significant increase of DNA damage was observed in non-neoplastic oral cells at four weeks of 4NQO administration when compared with control (P < 0.05). The level of DNA damage was directly associated with the severity of histological changes. The results suggest that histologically normal tissue is able to harbor genetically unstable cells contributing to the initiation of oral carcinogenesis. Genomic instability appears to be associated with the risk and progression of oral cancer. (C) 2004 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUNESP, Fac Med Botucatu, TOXICAN, Dept Patol Nucl Avaliacao Toxicogenet & Cancerige, BR-18618000 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Med Botucatu, TOXICAN, Dept Patol Nucl Avaliacao Toxicogenet & Cancerige, BR-18618000 São Paulo, Brazil
dc.format.extent910-915
dc.identifierhttp://dx.doi.org/10.1016/j.oraloncology.2004.04.010
dc.identifier.citationOral Oncology. Oxford: Pergamon-Elsevier B.V., v. 40, n. 9, p. 910-915, 2004.
dc.identifier.doi10.1016/j.oraloncology.2004.04.010
dc.identifier.issn1368-8375
dc.identifier.lattes5051118752980903
dc.identifier.urihttp://hdl.handle.net/11449/12823
dc.identifier.wosWOS:000224599800008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofOral Oncology
dc.relation.ispartofjcr4.636
dc.relation.ispartofsjr1,912
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsingle cell gel (comet) assaypt
dc.subjectoral cancerpt
dc.subject4-nitroquinoline 1-oxidept
dc.titleGenomic instability in non-neoplastic oral mucosa cells can predict risk during 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes5051118752980903
unesp.author.orcid0000-0001-9323-3134[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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