Titanium-35niobium alloy as a potential material for biomedical implants: in vitro study

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dc.contributor.authorAndrade, Dennia Perez de[UNESP]
dc.contributor.authorVasconcellos, Luana Marotta Reis de[UNESP]
dc.contributor.authorCarvalho, Isabel Chaves Silva [UNESP]
dc.contributor.authorForte, Lilibeth Ferraz de Brito Penna [UNESP]
dc.contributor.authorSouza Santos, Evelyn Luzia de [UNESP]
dc.contributor.authorPrado, Renata Falchete do [UNESP]
dc.contributor.authorSantos, Dalcy Roberto dos
dc.contributor.authorCairo, Carlos Alberto Alves
dc.contributor.authorCarvalho, Yasmin Rodarte [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionAir and Space Institute (CTA)
dc.date.accessioned2015-12-07T15:40:28Z
dc.date.available2015-12-07T15:40:28Z
dc.date.issued2015-11-01
dc.description.abstractResearch on new titanium alloys and different surface topographies aims to improve osseointegration. The objective of this study is to analyze the behavior of osteogenic cells cultivated on porous and dense samples of titanium-niobium alloys, and to compare them with the behavior of such type of cells on commercial pure titanium. Samples prepared using powder metallurgy were characterized using scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and metallographic and profilometer analyses. Osteogenic cells from newborn rat calvaria were plated over different groups: dense or porous samples composed of Ti or Ti-35niobium (Nb). Cell adhesion, cell proliferation, MTT assay, cell morphology, protein total content, alkaline phosphatase activity, and mineralization nodules were assessed. Results from XRD and EDS analysis confirmed the presence of Ti and Nb in the test alloy. Metallographic analysis revealed interconnected pores, with pore size ranging from 138 to 150μm. The profilometer analysis detected the greatest rugosity within the dense alloy samples. In vitro tests revealed similar biocompatibility between Ti-35Nb and Ti; furthermore, it was possible to verify that the association of porous surface topography and the Ti-35Nb alloy positively influenced mineralized matrix formation. We propose that the Ti-35Nb alloy with porous topography constitutes a biocompatible material with great potential for use in biomedical implants.en
dc.description.affiliationDivision of Materials, Air and Space Institute, CTA, Praça Mal. do Ar Eduardo Gomes, 14, São José dos Campos 12904-000, SP, Brazil
dc.description.affiliationUnespDepartment of Bioscience and Oral Diagnosis, Institute of Science and Technology, UNESP — Univ Estadual Paulista, State University of São Paulo (UNESP), Av. Engenheiro Francisco José Longo, 777, São José dos Campos 12245-000, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent538-544
dc.identifierhttp://dx.doi.org/10.1016/j.msec.2015.07.026
dc.identifier.citationMaterials Science & Engineering. C, Materials For Biological Applications, v. 56, p. 538-544, 2015.
dc.identifier.doi10.1016/j.msec.2015.07.026
dc.identifier.issn1873-0191
dc.identifier.lattes6967369119792151
dc.identifier.lattes5006685136114327
dc.identifier.pubmed26249625
dc.identifier.urihttp://hdl.handle.net/11449/131682
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofMaterials Science & Engineering. C, Materials For Biological Applications
dc.relation.ispartofsjr1,110
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectBiocompatibilityen
dc.subjectImplantsen
dc.subjectOsteogenesisen
dc.subjectPorous surfacesen
dc.subjectTitanium niobium alloyen
dc.titleTitanium-35niobium alloy as a potential material for biomedical implants: in vitro studyen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.lattes6967369119792151
unesp.author.lattes5006685136114327
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, São José dos Campospt

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