Chitosan/tripolyphosphate nanoparticles loaded with paraquat herbicide: An environmentally safer alternative for weed control

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dc.contributor.authorGrillo, Renato [UNESP]
dc.contributor.authorPereira, Anderson E. S. [UNESP]
dc.contributor.authorNishisaka, Caroline S.
dc.contributor.authorLima, Renata de
dc.contributor.authorOehlke, Kathleen
dc.contributor.authorGreiner, Ralf
dc.contributor.authorFraceto, Leonardo F. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniv Sorocaba
dc.contributor.institutionMax Rubner Inst
dc.date.accessioned2015-03-18T15:53:35Z
dc.date.available2015-03-18T15:53:35Z
dc.date.issued2014-08-15
dc.description.abstractParaquat is a fast acting nonselective contact herbicide that is extensively used worldwide. However, the aqueous solubility and soil sorption of this compound can cause problems of toxicity in nontarget organisms. This work investigates the preparation and characterization of nanoparticles composed of chitosan and sodium tripolyphosphate (TPP) to produce an efficient herbicidal formulation that was less toxic and could be used for safer control of weeds in agriculture. The toxicities of the formulations were evaluated using cell culture viability assays and the Allium cepa chromosome aberration test. The herbicidal activity was investigated in cultivations of maize (Zea mays) and mustard (Brassica sp.), and soil sorption of the nanoencapsulated herbicide was measured. The efficiency association of paraquat with the nanoparticles was 62.6 +/- 0.7%. Encapsulation of the herbicide resulted in changes in its diffusion and release as well as its sorption by soil. Cytotoxicity and genotoxicity assays showed that the nanoencapsulated herbicide was less toxic than the pure compound, indicating its potential to control weeds while at the same time reducing environmental impacts. Measurements of herbicidal activity showed that the effectiveness of paraquat was preserved after encapsulation. It was concluded that the encapsulation of paraquat in nanoparticles can provide a useful means of reducing adverse impacts on human health and the environment, and that the formulation therefore has potential for use in agriculture. (C) 2014 Elsevier B.V. All rights reserved.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP, Brazil
dc.description.affiliationUniv Sorocaba, Dept Biotechnol, Sorocaba, SP, Brazil
dc.description.affiliationMax Rubner Inst, Dept Food Technol & Bioproc Engn, Karlsruhe, Germany
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipIdFAPESP: 13/12322-2
dc.description.sponsorshipIdFAPESP: 11/01872-6
dc.format.extent163-171
dc.identifierhttp://dx.doi.org/10.1016/j.jhazmat.2014.05.079
dc.identifier.citationJournal Of Hazardous Materials. Amsterdam: Elsevier Science Bv, v. 278, p. 163-171, 2014.
dc.identifier.doi10.1016/j.jhazmat.2014.05.079
dc.identifier.issn0304-3894
dc.identifier.lattes2188736885721242
dc.identifier.orcid0000-0002-0284-5782
dc.identifier.urihttp://hdl.handle.net/11449/116608
dc.identifier.wosWOS:000340689100021
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal Of Hazardous Materials
dc.relation.ispartofjcr6.434
dc.relation.ispartofsjr1,787
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectEnvironmentally safe formulationsen
dc.subjectHerbicidesen
dc.subjectNanoparticlesen
dc.subjectGenotoxicityen
dc.titleChitosan/tripolyphosphate nanoparticles loaded with paraquat herbicide: An environmentally safer alternative for weed controlen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes2188736885721242[1]
unesp.author.orcid0000-0001-8712-1144[4]
unesp.author.orcid0000-0002-0284-5782[1]
unesp.author.orcid0000-0002-4776-6199[3]
unesp.author.orcid0000-0002-2827-2038[7]
unesp.author.orcid0000-0001-8526-6067[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Ciência e Tecnologia, Sorocabapt

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