Hematological changes and cytogenotoxicity in the tilapia Oreochromis niloticus caused by sub-chronic exposures to mercury and selenium

Página do item simplificado
dc.contributor.authorSeriani, Robson
dc.contributor.authorFranca, Jakeline Galvão [UNESP]
dc.contributor.authorLombardi, Julio Vicente
dc.contributor.authorBrito, Jôse Mara
dc.contributor.authorTavares Ranzani-Paiva, Maria José
dc.contributor.institutionInstituto de Pesca
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-10-21T20:33:00Z
dc.date.available2015-10-21T20:33:00Z
dc.date.issued2015-02-01
dc.description.abstractFish bioassays are valuable tools that can be used to elucidate the toxicological potential of numerous substances that are present in the aquatic environment. In this study, we assessed the antagonistic action of selenium (Se) against the toxicity of mercury (Hg) in fish (Oreochromis niloticus). Six experimental groups with six fish each were defined as follows: (1) control, (2) mercury (HgCl2), (3) sodium selenite (Na2Se4O3), (4) sodium selenate (Na2Se6O4), (5) mercury + sodium selenite (HgCl2 + Na2Se4O3), and (6) mercury + sodium selenate (HgCl2 + Na2Se6O4). Hematological parameters [red blood cells (RBC), white blood cells (WBC), and erythroblasts (ERB)] in combination with cytogenotoxicity biomarkers [nuclear abnormalities (NAs) and micronuclei (MN)] were examined after three, seven, ten, and fourteen days. After 7 days of exposure, cytogenotoxic effects and increased erythroblasts caused by mercury, leukocytosis triggered by mercury + sodium selenite, leukopenia associated with sodium selenate, and anemia triggered by mercury + sodium selenate were observed. Positive correlations that were independent of time were observed between WBC and RBC, ERB and MN, and NA and MN. The results suggest that short-term exposure to chemical contaminants elicited changes in blood parameters and produced cytogenotoxic effects. Moreover, NAs are the primary manifestations of MN formation and should be included in a class characterized as NA only. Lastly, the staining techniques used can be applied to both hematological characterization and the measurement of cytogenotoxicity biomarkers.en
dc.description.affiliationCentro de Aquicultura, Instituto de Pesca, Avenida Francisco Matarazzo, 455, São Paulo, SP, 05001-900, Brazil
dc.description.affiliationFaculdade de Medicina, Universidade de São Paulo, Avenida Dr. Arnaldo, 455-room 1150, São Paulo, SP, 01246-903, Brazil
dc.description.affiliationUnespCentro de Aquicultura, Campus Jaboticabal, Universidade Estadual Paulista, Via de Acesso Prof. Paulo Donato Castellane, s/n, Jaboticabal, SP, 14884-900, Brazil
dc.format.extent311-322
dc.identifierhttp://link.springer.com/article/10.1007%2Fs10695-014-9984-x
dc.identifier.citationFish Physiology And Biochemistry. Dordrecht: Springer, v. 41, n. 1, p. 311-322, 2015.
dc.identifier.doi10.1007/s10695-014-9984-x
dc.identifier.issn0920-1742
dc.identifier.urihttp://hdl.handle.net/11449/129184
dc.identifier.wosWOS:000348447700026
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofFish Physiology And Biochemistry
dc.relation.ispartofjcr1.735
dc.relation.ispartofsjr0,690
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectToxicityen
dc.subjectMercuryen
dc.subjectSeleniumen
dc.subjectHematologyen
dc.subjectNuclear abnormalitiesen
dc.subjectMicronucleien
dc.titleHematological changes and cytogenotoxicity in the tilapia Oreochromis niloticus caused by sub-chronic exposures to mercury and seleniumen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer

Arquivos

Coleções

Jaboticabal - CAUNESP - Centro de Aquicultura da Unesp