Could zinc prevent reproductive alterations caused by cigarette smoke in male rats?

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dc.contributor.authorGarcia, Patricia Carvalho [UNESP]
dc.contributor.authorPiffer, Renata Carolina [UNESP]
dc.contributor.authorCecatto Gerardin, Daniela Cristina
dc.contributor.authorSankako, Michele Kimie [UNESP]
dc.contributor.authorAlves de Lima, Rodrigo Otavio
dc.contributor.authorMarques Pereira, Oduvaldo Camara [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.date.accessioned2014-05-20T13:33:19Z
dc.date.available2014-05-20T13:33:19Z
dc.date.issued2012-01-01
dc.description.abstractThe aim of the present study was to evaluate the effects of zinc on fertility through semen parameters, testosterone level and oxidative DNA damage to spermatozoa of rats exposed to cigarette smoke. Male Wistar rats (60 days old) were divided into four groups (n = 10 per group): control, cigarette-smoking (20 cigarettes per day), zinc (zinc chloride 20 mg kg(-1) day(-1)) and zinc plus cigarette-smoking (zinc chloride 20 mg kg(-1) day(-1); 20 cigarettes per day). The treatment was applied for nine weeks and the following parameters were analysed: bodyweight, wet weights of the reproductive organs and the adrenal gland, plasma testosterone concentration, testicular function (seminal analysis and daily sperm production) and sperm DNA oxidative damage. The exposure to cigarette smoke decreased testosterone concentration, the percentage of normal morphology and the motility of spermatozoa. In addition, this exposure increased sperm DNA oxidative damage. Zinc treatment protected against the toxic damage that smoking caused to spermatozoa. This study showed a correlation between smoking and possible male infertility and subfertility, and also that the majority of smoking-induced changes in spermatozoa were prevented by zinc treatment. In conclusion, zinc, an antioxidant and stimulant of cell division, can be indicated as a promising treatment in men with infertility caused by the toxic components of cigarette smoke.en
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Clin Med, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Pharmacol, Inst Biosci, BR-18618970 São Paulo, Brazil
dc.description.affiliationLondrina State Univ UEL, Dept Physiol Sci, BR-86051990 Londrina, Parana, Brazil
dc.description.affiliationMaringa State Univ UEM, Ctr Hlth Sci, Basic Dept Hlth Pathol, BR-87020900 Maringa, Parana, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Clin Med, Botucatu Med Sch, BR-18618970 São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Pharmacol, Inst Biosci, BR-18618970 São Paulo, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent559-567
dc.identifierhttp://dx.doi.org/10.1071/RD10063
dc.identifier.citationReproduction Fertility and Development. Collingwood: Csiro Publishing, v. 24, n. 4, p. 559-567, 2012.
dc.identifier.doi10.1071/RD10063
dc.identifier.issn1031-3613
dc.identifier.urihttp://hdl.handle.net/11449/11393
dc.identifier.wosWOS:000303123800005
dc.language.isoeng
dc.publisherCSIRO Publishing
dc.relation.ispartofReproduction, Fertility and Development
dc.relation.ispartofjcr2.105
dc.relation.ispartofsjr0,681
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectsemen parametersen
dc.subjectspermatozoaen
dc.subjecttesticular functionen
dc.titleCould zinc prevent reproductive alterations caused by cigarette smoke in male rats?en
dc.typeArtigo
dcterms.licensehttp://www.publish.csiro.au/nid/36.htm
dcterms.rightsHolderCsiro Publishing
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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