The Use of Etoricoxib and Celecoxib for Pain Prevention After Periodontal Surgery: A Double-Masked, Parallel-Group, Placebo-Controlled, Randomized Clinical Trial

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dc.contributor.authorSteffens, Joao Paulo
dc.contributor.authorSantos, Fabio Andre
dc.contributor.authorPilatti, Gibson Luiz
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Ponta Grossa (UEPG)
dc.date.accessioned2014-05-20T15:31:49Z
dc.date.available2014-05-20T15:31:49Z
dc.date.issued2011-09-01
dc.description.abstractBackground: Postoperative pain is an adverse effect of periodontal surgeries and may therefore be prevented or minimized. This study was conducted to evaluate the clinical efficacy of two selective cyclooxygenase-2 inhibitors, celecoxib and etoricoxib, on pain prevention after periodontal surgery.Methods: For this double-masked, parallel-group, placebo-controlled, and randomized clinical trial, 56 open-flap debridement surgeries were performed. The groups received three different protocols 1 hour before surgery: 1) 200 mg celecoxib (and another 200 mg 12 hours after the first dose); 2) 120 mg etoricoxib; or 3) placebo. Pain intensity and discomfort were assessed up to 2 days after surgery using the visual analog scale and the four-point verbal rating scale, respectively. Patients were instructed to take 750 mg acetaminophen as a rescue medication if necessary.Results: Pain intensity levels in the etoricoxib group were lower than in the placebo group at the 2-, 3-, 4-, 5-, 6-, and 7-hour periods after surgery (Kruskal-Wallis test; P < 0.05). There was no statistically significant difference between celecoxib and etoricoxib. Discomfort in the celecoxib group was significantly lower than in the placebo group only at the 3-hour period (P = 0.03). Rescue medication intake was significantly less frequent in the etoricoxib group than in the placebo and celecoxib groups (analysis of variance; P = 0.009).Conclusion: It was concluded that a single etoricoxib dose is not superior to two split doses of celecoxib when used for pain prevention after open-flap debridement surgery. J Periodontol 2011;82:1238-1244.en
dc.description.affiliationUniv Estadual Paulista UNESP, Araraquara Dent Sch, Araraquara, SP, Brazil
dc.description.affiliationUniversidade Estadual de Ponta Grossa (UEPG), Dept Periodontol, Postgraduat Dent Program, Ponta Grossa, Parana, Brazil
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Araraquara Dent Sch, Araraquara, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent1238-1244
dc.identifierhttp://dx.doi.org/10.1902/jop.2011.100682
dc.identifier.citationJournal of Periodontology. Chicago: Amer Acad Periodontology, v. 82, n. 9, p. 1238-1244, 2011.
dc.identifier.doi10.1902/jop.2011.100682
dc.identifier.issn0022-3492
dc.identifier.urihttp://hdl.handle.net/11449/40860
dc.identifier.wosWOS:000295726000002
dc.language.isoeng
dc.publisherAmer Acad Periodontology
dc.relation.ispartofJournal of Periodontology
dc.relation.ispartofjcr3.392
dc.relation.ispartofsjr1,408
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectAnalgesiaen
dc.subjectcelecoxiben
dc.subjectetoricoxiben
dc.subjectpain measurementen
dc.subjectpainen
dc.subjectpostoperativeen
dc.subjectpreanesthetic medicationen
dc.titleThe Use of Etoricoxib and Celecoxib for Pain Prevention After Periodontal Surgery: A Double-Masked, Parallel-Group, Placebo-Controlled, Randomized Clinical Trialen
dc.typeArtigo
dcterms.licensehttp://www.joponline.org/page/permissionRequests.jsp
dcterms.rightsHolderAmer Acad Periodontology

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