Clinical and laboratory description of a series of cases of acute viral myositis

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dc.contributor.authorCardin, Silvana Paula [UNESP]
dc.contributor.authorMartin, Joelma Gonçalves [UNESP]
dc.contributor.authorSaad-Magalhães, Claudia [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:31:47Z
dc.date.available2015-12-07T15:31:47Z
dc.date.issued2015
dc.description.abstractDescribe the clinical and laboratory profile, follow-up, and outcome of a series of cases of acute viral myositis. A retrospective analysis of suspected cases under observation in the emergency department was performed, including outpatient follow-up with the recording of respiratory infection and musculoskeletal symptoms, measurement of muscle enzymes, creatine phosphokinase (CPK), lactate dehydrogenase (LDH), transaminases (AST and ALT), blood count, C-reactive protein, and erythrocyte sedimentation rate in the acute phase and during follow-up until normalization. Between 2000 and 2009, 42 suspected cases were identified and 35 (27 boys) were included. The median age was 7 years and the diagnosis was reported in 89% in the first emergency visit. The observed respiratory symptoms were cough (31%), rhinorrhea (23%), and fever (63%), with a mean duration of 4.3 days. Musculoskeletal symptoms were localized pain in the calves (80%), limited ambulation (57%), gait abnormality (40%), and muscle weakness in the lower limbs (71%), with a mean duration of 3.6 days. There was significant increase in CPK enzymes (5507±9180U/L), LDH (827±598U/L), and AST (199±245U/L), with a tendency to leukopenia (4590±1420) leukocytes/mm(3). The complete recovery of laboratory parameters was observed in 30 days (median), and laboratory and clinical recurrence was documented in one case after 10 months. Typical symptoms with increased muscle enzymes after diagnosis of influenza and self-limited course of the disease were the clues to the diagnosis. The increase in muscle enzymes indicate transient myotropic activity related to seasonal influenza, which should be considered, regardless of the viral identification, possibly associated with influenza virus or other respiratory viruses.en
dc.description.affiliationDepartment of Pediatrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
dc.description.affiliationDepartment of Pediatrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil. Electronic address: claudi@fmb.unesp.br.
dc.description.affiliationUnespDepartment of Pediatrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
dc.description.affiliationUnespDepartment of Pediatrics, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil. Electronic address: claudi@fmb.unesp.br.
dc.format.extent442-447
dc.identifierhttp://dx.doi.org/10.1016/j.jped.2014.11.008
dc.identifier.citationJornal De Pediatria, v. 91, n. 5, p. 442-447, 2015.
dc.identifier.doi10.1016/j.jped.2014.11.008
dc.identifier.fileS0021-75572015000500442.pdf
dc.identifier.issn1678-4782
dc.identifier.lattes7098310008371632
dc.identifier.orcid0000-0002-7631-7093
dc.identifier.pubmed26054774
dc.identifier.scieloS0021-75572015000500442
dc.identifier.urihttp://hdl.handle.net/11449/131122
dc.language.isoeng
dc.publisherElsevier B. V.
dc.relation.ispartofJornal De Pediatria
dc.rights.accessRightsAcesso aberto
dc.sourcePubMed
dc.subjectAcute myositisen
dc.subjectCreatina-fosfoquinaseen
dc.subjectCreatine phosphokinaseen
dc.subjectInfluenzaen
dc.subjectMiosite agudaen
dc.titleClinical and laboratory description of a series of cases of acute viral myositisen
dc.typeArtigo
dcterms.rightsHolderElsevier B. V.
unesp.author.lattes7098310008371632[3]
unesp.author.orcid0000-0002-7631-7093[3]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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