Central muscarinic receptors signal pilocarpine-induced salivation

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dc.contributor.authorTakakura, ACT
dc.contributor.authorMoreira, T. S.
dc.contributor.authorLaitano, S. C.
dc.contributor.authorDe Luca, L. A.
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:45:48Z
dc.date.available2014-05-20T13:45:48Z
dc.date.issued2003-12-01
dc.description.abstractAlthough cholinergic agonists such as pilocarpine injected peripherally can act directly on salivary glands to induce salivation, it is possible that their action in the brain may contribute to salivation. To investigate if the action in the brain is important to salivation, we injected pilocarpine intraperitoneally after blockade of central cholinergic receptors with atropine methyl bromide (atropine-mb). In male Holtzman rats with stainless steel cannulas implanted into the lateral ventricle and anesthetized with ketamine, atropine-mb (8 and 16 nmol) intracerebroventricularly reduced the salivation induced by pilocarpine (4 mumol/kg) intraperitoneally (133 +/- 42 and 108 +/- 22 mg/7 min, respectively, vs. saline, 463 +/- 26 mg/7 min), but did not modify peripheral cardiovascular responses to intravenous acetylcholine. Similar doses of atropine-mb intraperitoneally also reduced pilocarpine-induced salivation. Therefore, systemically injected pilocarpine also enters the brain and acts on central muscarinic receptors, activating autonomic efferent fibers to induce salivation.en
dc.description.affiliationUniv Estadual Paulista, Dept Physiol & Pathol, Sch Dent, UNESP, BR-14801903 Araraquara, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Dept Physiol & Pathol, Sch Dent, UNESP, BR-14801903 Araraquara, SP, Brazil
dc.format.extent993-997
dc.identifierhttp://dx.doi.org/10.1177/154405910308201211
dc.identifier.citationJournal of Dental Research. Thousand Oaks: Sage Publications Inc., v. 82, n. 12, p. 993-997, 2003.
dc.identifier.doi10.1177/154405910308201211
dc.identifier.issn0022-0345
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.urihttp://hdl.handle.net/11449/16154
dc.identifier.wosWOS:000186818500011
dc.language.isoeng
dc.publisherSage Publications Inc
dc.relation.ispartofJournal of Dental Research
dc.relation.ispartofjcr5.380
dc.relation.ispartofsjr2,302
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectmuscarinic receptorspt
dc.subjectacetylcholinept
dc.subjectatropinept
dc.subjectsalivary glandspt
dc.subjectparasympatheticpt
dc.titleCentral muscarinic receptors signal pilocarpine-induced salivationen
dc.typeArtigo
dcterms.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dcterms.rightsHolderSage Publications Inc
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.orcid0000-0002-9789-8296[2]
unesp.author.orcid0000-0003-1167-4441[6]
unesp.author.orcid0000-0001-8270-2652[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Odontologia, Araraquarapt

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