Managing chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment time

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dc.contributor.authorBelda, Walter
dc.contributor.authorCasolato, Ana Thereza Stradioto
dc.contributor.authorLuppi, Juliana Bronzato
dc.contributor.authorPassero, Luiz Felipe Domingues [UNESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.date.accessioned2022-04-29T08:45:40Z
dc.date.available2022-04-29T08:45:40Z
dc.date.issued2021-10-01
dc.description.abstractChromoblastomycosis (CBM) is an infectious disease caused by fungi that is prevalent in tropical and subtropical countries. Besides few therapeutic options, the classical treatment of CBM needs to be administrated for a long period of time, and unfortunately some patients do not show improvement of the lesions. Thus, it becomes urgent to develop new strategies for the treatment of CBM. This work reports a successful treatment, performed with the combination of oral acitretin (50 mg/kg, once a day) plus topical imiquimod (50 mg/g, five times per week) for 5 months in a patient with CBM. A significant improvement of the lesions was observed in the 1st month, and in the 5th a complete regression of lesions was recorded. Changes in the biochemical parameters were not observed. These data suggest that the combination of acitretin and imiquimod may be effective at treating CBM.en
dc.description.affiliationDermatology Department Medical School Clinics Hospital University of São Paulo
dc.description.affiliationLaboratory of Pathology of Infectious Diseases Medical School University of São Paulo
dc.description.affiliationDermatology Division Medical School Clinics Hospital University of São Paulo
dc.description.affiliationSão Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute of Biosciences
dc.description.affiliationUnespSão Paulo State University (UNESP) Institute for Advanced Studies of Ocean
dc.format.extent1612-1615
dc.identifierhttp://dx.doi.org/10.1111/1346-8138.16101
dc.identifier.citationJournal of Dermatology, v. 48, n. 10, p. 1612-1615, 2021.
dc.identifier.doi10.1111/1346-8138.16101
dc.identifier.issn1346-8138
dc.identifier.issn0385-2407
dc.identifier.scopus2-s2.0-85112861437
dc.identifier.urihttp://hdl.handle.net/11449/231496
dc.language.isoeng
dc.relation.ispartofJournal of Dermatology
dc.sourceScopus
dc.subjectacitretin
dc.subjectchromoblastomycosis
dc.subjectimiquimod
dc.subjectlesion evolution
dc.subjecttreatment
dc.titleManaging chromoblastomycosis with acitretin plus imiquimod: A case report on the improvement of cutaneous lesions and reduction of the treatment timeen
dc.typeArtigo
unesp.author.orcid0000-0003-0401-1885[1]
unesp.author.orcid0000-0002-5986-6381[4]

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Artigos - Dermatologia e Radioterapia - FMB
Artigos - Patologia - FMB