Thyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndrome

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dc.contributor.authorCampanha, Fábio V.G. [UNESP]
dc.contributor.authorPerone, Denise [UNESP]
dc.contributor.authorde Campos, Dijon H.S. [UNESP]
dc.contributor.authorde Luvizotto, Renata A. M.
dc.contributor.authorde Síbio, Maria T. [UNESP]
dc.contributor.authorde Oliveira, Miriane [UNESP]
dc.contributor.authorOlimpio, Regiane M. C. [UNESP]
dc.contributor.authorMoretto, Fernanda C. F. [UNESP]
dc.contributor.authorPadovani, Carlos R. [UNESP]
dc.contributor.authorMazeto, Gláucia M.F.S. [UNESP]
dc.contributor.authorCicogna, Antonio C. [UNESP]
dc.contributor.authorNogueira, Célia R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)
dc.date.accessioned2018-12-11T17:08:19Z
dc.date.available2018-12-11T17:08:19Z
dc.date.issued2016-01-01
dc.description.abstractObjective: The current study was aimed at analyzing sarcoplasmic reticulum Ca2+ ATPase (Serca2) and ryanodine receptor type 2 (Ryr2) gene expression in rats subjected to surgery that induced HF and were subsequently treated with T4 using physiological doses. Materials and methods: HF was induced in 18 male Wistar rats by clipping the ascending thoracic aorta to generate aortic stenosis (HFS group), while the control group (9-sham) underwent thoracotomy. After 21 weeks, the HFS group was subdivided into two subgroups. One group (9 Wistar rats) with HF received 1.0 µg of T4/100 g of body weight for five consecutive days (HFS/T4); the other group (9 Wistar rats) received isotonic saline solution (HFS/S). The animals were sacrificed after this treatment and examined for signs of HF. Samples from the left ventricles of these animals were analyzed by RT-qPCR for the expression of Serca2 and Ryr2 genes. Results: Rats with HF developed euthyroid sick syndrome (ESS) and treatment with T4 restored the T3 values to the Sham level and increased Serca2 and Ryr2 gene expression, thereby demonstrating a possible benefit of T4 treatment for heart function in ESS associated with HF. Conclusion: The T4 treatment can potentially normalize the levels of T3 as well elevated Serca2 and Ryr2 gene expression in the myocardium in heart failure rats with euthyroid sick syndrome.en
dc.description.affiliationDepartamento de Clínica Médica Unidade de Pesquisa Experimental (Unipex) Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp)
dc.description.affiliationInstituto de Ciências da Saúde Universidade Federal de Mato Grosso (UFMT)
dc.description.affiliationDepartamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartamento de Clínica Médica Unidade de Pesquisa Experimental (Unipex) Faculdade de Medicina de Botucatu Universidade Estadual Paulista (Unesp)
dc.description.affiliationUnespDepartamento de Bioestatística Instituto de Biociências Universidade Estadual Paulista (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2007/55902-8
dc.format.extent582-586
dc.identifierhttp://dx.doi.org/10.1590/2359-3997000000208
dc.identifier.citationArchives of Endocrinology and Metabolism, v. 60, n. 6, p. 582-586, 2016.
dc.identifier.doi10.1590/2359-3997000000208
dc.identifier.fileS2359-39972016000600582.pdf
dc.identifier.issn2359-4292
dc.identifier.issn2359-3997
dc.identifier.scieloS2359-39972016000600582
dc.identifier.scopus2-s2.0-85006051848
dc.identifier.urihttp://hdl.handle.net/11449/173914
dc.language.isoeng
dc.relation.ispartofArchives of Endocrinology and Metabolism
dc.relation.ispartofsjr0,505
dc.relation.ispartofsjr0,505
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCalcium channels
dc.subjectHeart failure
dc.subjectReverse triiodothyronine
dc.subjectTherapeutic use
dc.subjectTriiodothyronine
dc.titleThyroxine increases Serca2 and Ryr2 gene expression in heart failure rats with euthyroid sick syndromeen
dc.typeArtigo
unesp.author.lattes9418970103564137[11]
unesp.author.lattes8727897080522289[9]
unesp.author.lattes7607038776901890[12]
unesp.author.orcid0000-0002-4402-6523[11]
unesp.author.orcid0000-0002-7719-9682[9]
unesp.author.orcid0000-0002-4014-0660[12]

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