Th1/Th2/Th17/Treg Balance in Apical Periodontitis of Normoglycemic and Diabetic Rats

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dc.contributor.authorSamuel, Renata Oliveira [UNESP]
dc.contributor.authorErvolino, Edilson [UNESP]
dc.contributor.authorde Azevedo Queiroz, Índia Olinta [UNESP]
dc.contributor.authorAzuma, Mariane Maffei [UNESP]
dc.contributor.authorFerreira, Gabriela Tiago
dc.contributor.authorCintra, Luciano Tavares Angelo [UNESP]
dc.contributor.institutionUniversidade de Uberaba Dental School
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Michigan
dc.date.accessioned2019-10-06T17:11:56Z
dc.date.available2019-10-06T17:11:56Z
dc.date.issued2019-08-01
dc.description.abstractIntroduction: The aim of this study was to evaluate the inflammatory profile of T helper (Th) cells in normoglycemic (N) and diabetic rats with apical periodontitis (AP). Methods: Twenty male Wistar rats were divided in 2 groups: N rats and rats with diabetes mellitus (DM). DM was induced using streptozotocin, and AP was induced by dental pulp exposure of the first mandibular molar to the oral environment. After 30 days, the mandibles were removed and processed for histologic analysis, bacterial analysis, and immunochemical assays for interleukin (IL)-6, tumor necrosis factor alpha, IL-17, IL-23, interferon gamma, and IL-10. The Mann-Whitney U test and Student t test were used for statistical analysis (P <.05). Results: The DM group showed more intense inflammatory infiltrate with larger sizes of bone reabsorption and a greater presence of bacteria than the N group (P <.05). Proinflammatory cytokine levels in the DM group were also greater than those in the N group (P <.05). However, interferon gamma was more intense in the N group than in the DM group (P <.05). Conclusions: The inflammatory profile of AP in DM is different from that in the N group, suggesting that Th1 is a secondary strain and the Th17 strain is predominant in DM.en
dc.description.affiliationDepartment of Clinical Dentistry Universidade de Uberaba Dental School
dc.description.affiliationDepartment of Endodontics School of Dentistry São Paulo State University - UNESP
dc.description.affiliationDepartment of Basic Science School of Dentistry São Paulo State University - UNESP
dc.description.affiliationDepartment of Cariology Restorative Sciences and Endododontics University of Michigan
dc.description.affiliationUnespDepartment of Endodontics School of Dentistry São Paulo State University - UNESP
dc.description.affiliationUnespDepartment of Basic Science School of Dentistry São Paulo State University - UNESP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/23358-8
dc.format.extent1009-1015
dc.identifierhttp://dx.doi.org/10.1016/j.joen.2019.05.003
dc.identifier.citationJournal of Endodontics, v. 45, n. 8, p. 1009-1015, 2019.
dc.identifier.doi10.1016/j.joen.2019.05.003
dc.identifier.issn0099-2399
dc.identifier.lattes4408095517346846
dc.identifier.lattes9235743081667362
dc.identifier.orcid0000-0003-4859-0583
dc.identifier.scopus2-s2.0-85067294992
dc.identifier.urihttp://hdl.handle.net/11449/190401
dc.language.isoeng
dc.relation.ispartofJournal of Endodontics
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectApical periodontitis
dc.subjectdiabetes mellitus
dc.subjectinflammation
dc.titleTh1/Th2/Th17/Treg Balance in Apical Periodontitis of Normoglycemic and Diabetic Ratsen
dc.typeArtigo
unesp.author.lattes4408095517346846[2]
unesp.author.lattes9235743081667362
unesp.author.orcid0000-0003-2348-7846[6]
unesp.author.orcid0000-0003-4859-0583[2]

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Artigos - Ciências Básicas - FOA
Artigos - Odontologia Restauradora - FOA