Training improves the oxidative phenotype of muscle during the transition from cardiac hypertrophy to heart failure without altering MyoD and myogenin

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dc.contributor.authorPacagnelli, Francis Lopes
dc.contributor.authorAguiar, Andreo Fernando
dc.contributor.authorCampos, Dijon Henrique S. [UNESP]
dc.contributor.authorCastan, Eduardo Paulino [UNESP]
dc.contributor.authorde Souza, Rodrigo Wagner Alves [UNESP]
dc.contributor.authorde Almeida, Fernanda Losi Alves
dc.contributor.authorCarani, Fernanda
dc.contributor.authorCarvalho, Robson Francisco [UNESP]
dc.contributor.authorCicogna, Antonio Carlos [UNESP]
dc.contributor.authorSilva, Maeli Dal Pai [UNESP]
dc.contributor.institutionUNOESTE
dc.contributor.institutionUNOPAR
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade Estadual de Maringá (UEM)
dc.date.accessioned2018-12-11T17:29:20Z
dc.date.available2018-12-11T17:29:20Z
dc.date.issued2016-08-01
dc.description.abstractNew Findings: What is the central question of this study? We investigated the effects of physical training on phenotypic (fibre-type content) and myogenic features (MyoD and myogenin expression) in skeletal muscle during the transition from cardiac hypertrophy to heart failure. What is the main finding and its importance? We provide new insight into skeletal muscle adaptations by showing that physical training increases the type I fibre content during the transition from cardiac hypertrophy to heart failure, without altering MyoD and myogenin expression. These results have important clinical implications for patients with heart failure, because this population has reduced muscle oxidative capacity. The purpose of this study was to investigate the effects of physical training (PT) on phenotypic features (fibre-type content) and myogenic regulatory factors (MyoD and myogenin) in rat skeletal muscle during the transition from cardiac hypertrophy to heart failure. We used the model of ascending aortic stenosis (AS) to induce heart failure in male Wistar rats. Sham-operated animals were used as age-matched controls. At 18 weeks after surgery, rats with ventricular dysfunction were randomized into the following four groups: sham-operated, untrained (Sham-U; n = 8); sham-operated, trained (Sham-T; n = 6); aortic stenosis, untrained (AS-U; n = 6); and aortic stenosis, trained (AS-T; n = 8). The AS-T and Sham-T groups were submitted to a 10 week aerobic PT programme, while the AS-U and Sham-U groups remained untrained for the same period of time. After the PT programme, the animals were killed and the soleus muscles collected for phenotypic and molecular analyses. Physical training promoted type IIa-to-I fibre conversion in the trained groups (Sham-T and AS-T) compared with the untrained groups (Sham-U and AS-U). No significant (P > 0.05) differences were found in type I or IIa fibre content in the AS-U group compared with the Sham-U group. Additionally, there were no significant (P > 0.05) differences in the myogenic regulatory factors MyoD and myogenin (gene and protein) expression between the groups. Therefore, our results indicate that PT may be a suitable strategy to improve the oxidative phenotype in skeletal muscle during the transition from cardiac hypertrophy to heart failure, without altering MyoD and myogenin.en
dc.description.affiliationDepartment of Physiotherapy UNOESTE
dc.description.affiliationCenter of Research in Health Sciences UNOPAR
dc.description.affiliationDepartment of Internal Medicine UNESP
dc.description.affiliationDepartment of Morphology UNESP
dc.description.affiliationDepartment of Morphological Science UEM
dc.description.affiliationUnespDepartment of Internal Medicine UNESP
dc.description.affiliationUnespDepartment of Morphology UNESP
dc.format.extent1075-1085
dc.identifierhttp://dx.doi.org/10.1113/EP085552
dc.identifier.citationExperimental Physiology, v. 101, n. 8, p. 1075-1085, 2016.
dc.identifier.doi10.1113/EP085552
dc.identifier.issn1469-445X
dc.identifier.issn0958-0670
dc.identifier.scopus2-s2.0-84982972432
dc.identifier.urihttp://hdl.handle.net/11449/178212
dc.language.isoeng
dc.relation.ispartofExperimental Physiology
dc.relation.ispartofsjr1,238
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectaortic stenosis
dc.subjectexercise training
dc.subjectheart failure
dc.titleTraining improves the oxidative phenotype of muscle during the transition from cardiac hypertrophy to heart failure without altering MyoD and myogeninen
dc.typeArtigo
unesp.author.lattes9418970103564137[9]
unesp.author.orcid0000-0002-4402-6523[9]

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