Intense exercise and endurance-training program influence serum kinetics of muscle and cardiac biomarkers in dogs

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dc.contributor.authorCerqueira, Juliana Aparecida [UNESP]
dc.contributor.authorZamora Restan, Wilmer Alejandro [UNESP]
dc.contributor.authorFonseca, Mayara Goncalves [UNESP]
dc.contributor.authorCatananti, Lucas Azevedo [UNESP]
dc.contributor.authorMendes de Almeida, Maria Luiza [UNESP]
dc.contributor.authorFeringer Junior, Walter Heinz [UNESP]
dc.contributor.authorPereira, Gener Tadeu [UNESP]
dc.contributor.authorCarciofi, Aulus Cavalieri [UNESP]
dc.contributor.authorFerraz, Guilherme de Camargo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-05T04:10:17Z
dc.date.available2019-10-05T04:10:17Z
dc.date.issued2018-12-01
dc.description.abstractFew data exist on the physiological consequences of an incremental exercise test (IET) and training in dogs. Here we evaluated the effect of an endurance-training program (ETP) on the kinetics of the serum biomarkers: creatine kinase (CK), aspartate aminotransferase (AST), myoglobin, cardiac troponin I (cTnI), and creatine kinase isoenzyme MB (CK-MB). Eighteen Beagle dogs were assigned to three groups: sedentary (S), untrained (U), and trained (T). The dogs from the groups T and U underwent IET, and their lactate threshold (LT) was determined. The LT and velocity corresponding to the LT (VLT) was determined by visual inspection. The VLT was utilized to determine the training intensity level. Thus, the dogs from group T underwent an eight-week aerobic conditioning program with the intensity training set to 70-80% of the VLT. Next, dogs from the groups T and U have submitted to IET again. The group S did not undergo IETs or training. The maximal velocity (Vmax) at which the dog achieves in the IET and heart rate were determined. For biomarkers, venous blood samples were collected before the experimental procedure (baseline) and before and 1, 6, 12, 24, 48, and 72 h after the IETs. VLT and Vmax increased in group T (P < .05), indicating an improvement in dogs' aerobic and anaerobic fitness. CK and AST rose (P < .05), peaking 6 h after both IETs and returning to baseline levels after 12-24 h. Levels of cTnI and myoglobin were unaltered. CK-MB peaked 1 h after the IETs and returned to baseline levels after 12 h (P < .05). We concluded that ETP improved the aerobic capacity of the dogs without any skeletal or cardiac muscle injury.en
dc.description.affiliationSao Paulo State Univ UNESP, Sch Agr & Veterinarian Sci, BR-14884900 Jaboticabal, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ UNESP, Sch Agr & Veterinarian Sci, BR-14884900 Jaboticabal, SP, Brazil
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2013/00449-8
dc.format.extent31-39
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.201.8.10.004
dc.identifier.citationResearch In Veterinary Science. Oxford: Elsevier Sci Ltd, v. 121, p. 31-39, 2018.
dc.identifier.doi10.1016/j.rvsc.201.8.10.004
dc.identifier.issn0034-5288
dc.identifier.urihttp://hdl.handle.net/11449/186512
dc.identifier.wosWOS:000451937600006
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofResearch In Veterinary Science
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectcreatine kinase
dc.subjectaspartate aminotransferase
dc.subjectmyoglobin
dc.subjectcardiac troponin I
dc.subjectlactate
dc.subjectheart rate
dc.titleIntense exercise and endurance-training program influence serum kinetics of muscle and cardiac biomarkers in dogsen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.lattes4620650316029248[8]
unesp.author.orcid0000-0002-3057-4115[7]
unesp.author.orcid0000-0003-3859-3983[8]

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