Lack of protective effects of zinc gluconate against rat colon carcinogenesis

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dc.contributor.authorDa Silva, Flávia Regina Moraes [UNESP]
dc.contributor.authorDias, Marcos Correa [UNESP]
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorRodrigues, Maria Aparecida Marchesan [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:02Z
dc.date.available2014-05-27T11:29:02Z
dc.date.issued2013-05-01
dc.description.abstractZinc has been proposed as a promising chemopreventive candidate against colon cancer. However, few studies on the potential beneficial effects of this trace element on cancer chemoprevention are available. The present study was designed to investigate the potential modifying influence of zinc gluconate (ZnGly) on the initiation step of colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). Male Wistar rats received orally ZnGly (15 mg elemental zinc/kg, 3 times per wk) 2 wk before and during DMH treatment (3 × 40 mg/kg, once a wk). The animals were euthanized at the end of 4th and 16th wk. Colons were analyzed for aberrant crypt foci (ACF) and tumor development. Blood and colon zinc levels, cell proliferation, and apoptosis indexes in colonic crypts were analyzed 24 h after the last DMH administration. Oral treatment with ZnGly did neither alter the number of ACF nor the indexes of cell proliferation and apoptosis in the colonic mucosa. The incidence and multiplicity of colon tumors induced by DMH and their histopathological patterns were not modified by previous treatment with ZnGly. These findings indicate a lack of chemopreventive action of zinc gluconate supplementation on the initiation step of rat colon carcinogenesis induced by DMH. © 2013 Copyright Taylor and Francis Group, LLC.en
dc.description.affiliationDepartment of Pathology Botucatu Medical School Sao Paulo State University, Rubiao Junior, s/n, Sao Paulo 18618-0970
dc.description.affiliationDepartment of Morphology Institute of Bioscience Sao Paulo State University, Botucatu, Sao Paulo
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School Sao Paulo State University, Rubiao Junior, s/n, Sao Paulo 18618-0970
dc.description.affiliationUnespDepartment of Morphology Institute of Bioscience Sao Paulo State University, Botucatu, Sao Paulo
dc.format.extent571-577
dc.identifierhttp://dx.doi.org/10.1080/01635581.2013.775317
dc.identifier.citationNutrition and Cancer, v. 65, n. 4, p. 571-577, 2013.
dc.identifier.doi10.1080/01635581.2013.775317
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.lattes3278528112652257
dc.identifier.scopus2-s2.0-84877940657
dc.identifier.urihttp://hdl.handle.net/11449/75243
dc.identifier.wosWOS:000318973200007
dc.language.isoeng
dc.relation.ispartofNutrition and Cancer
dc.relation.ispartofjcr2.261
dc.relation.ispartofsjr0,745
dc.relation.ispartofsjr0,745
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectgluconate zinc
dc.subjectaberrant crypt focus
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectapoptosis
dc.subjectcell proliferation
dc.subjectchemoprophylaxis
dc.subjectcolon carcinogenesis
dc.subjectcolon mucosa
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjecthistopathology
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectzinc blood level
dc.titleLack of protective effects of zinc gluconate against rat colon carcinogenesisen
dc.typeArtigo
dcterms.licensehttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
unesp.author.lattes3278528112652257
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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