Atividade livre na caixa associada ao ganho de peso e restauração das propriedades estruturais e mecânicas de osso em ratos jovens após hiposinesia de membros pélvicos

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dc.contributor.authorBarbosa, Adelton Andrade
dc.contributor.authorDel Carlo, Ricardo Junqueira
dc.contributor.authorGalvão, Simone Rezende
dc.contributor.authorLouzada, Mário Jefferson Quirino [UNESP]
dc.contributor.authorFranco, Frederico Souzalima Caldoncelli
dc.contributor.authorFernandes, Bárbara Braga
dc.contributor.authorCarneiro-Junior, Miguel Araújo
dc.contributor.authorRamos, Regiane Maria Soares
dc.contributor.authorDrummond, Lucas Rios
dc.contributor.authorNatali, Antonio Jose
dc.contributor.institutionInstituto de Ortopedia e Traumatologia
dc.contributor.institutionUniversidade Federal de Viçosa (UFV)
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionCiência e Tecnologia
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)
dc.date.accessioned2022-04-29T08:49:11Z
dc.date.available2022-04-29T08:49:11Z
dc.date.issued2012-07-01
dc.description.abstractWe investigated the importance of daily free activity in the cage and body weight gain during the recovering of bone structural and mechanical properties in growing rats after hindlimb unloading. Eight-week-old male Wistar rats were randomly divided into control (CG, n=24) and suspended (SG, n=24) groups. Animals from SG underwent a four-week hindlimb unloading period by tail-suspension. Animals from CG and those from SG after release were kept in collective cages and sacrificed at the age of 12, 16 and 20 weeks. Both femurs were removed and its area, bone mineral density (BMD), resistance to failure and stiffness were determined. Four-week hindlimb unloading decreased (p<0.05) body weight (CG, 373.00 ± 9.47 vs. SG, 295.86 ± 9.19 g), BMD (CG, 0.19 ± 0.01 vs. SG, 0.15 ± 0.01 g/cm 2), bone resistance to failure (CG, 147.75 ± 5.05 vs. SG, 96.40 ± 5.95 N) and stiffness (CG, 0.38 ± 0.01 vs. SG, 0.23 ± 0.02 N/m). Eight weeks of free activity in cage recovered (p>0.05) the body weight (CG, 472.75 ± 14.11 vs. SG, 444.75 ± 18.91 g), BMD (CG, 0.24 ± 0.01 vs. SG, 0.22 ± 0.01 g/cm 2), bone resistance to failure (CG, 195.73 ± 10.06 vs. SG, 178.45 ± 8.48 N) and stiffness (CG, 0.56 ± 0.02 vs. SG, 0.47± 0.03 N/m) of SG animals. Body weight correlated strongly with bone structural and mechanical properties (p<0.0001). In conclusion, free activity in the cage associated with body weight gain restored bone structural and mechanical properties in growing rats after hindlimb unloading.en
dc.description.affiliationInstituto de Ortopedia e Traumatologia, Ubá, MG
dc.description.affiliationUniversidade Federal de Viçosa - UFV, Viçosa, MG
dc.description.affiliationEscola de Medicina Veterinária Universidade Estadual Paulista, Araçatuba, SP
dc.description.affiliationInstituto Federal de Educação Ciência e Tecnologia, Rio Pomba, MG
dc.description.affiliationBiologia Celular e Estrutural UFV, Viçosa, MG
dc.description.affiliationCiências Fisiológicas Universidade Federal do Espírito Santo, Vitória, ES
dc.description.affiliationEducação Física - UFV, Viçosa, MG
dc.description.affiliationDepartamento de Educação Física UFV, Viçosa, MG
dc.description.affiliationUnespEscola de Medicina Veterinária Universidade Estadual Paulista, Araçatuba, SP
dc.format.extent660-666
dc.identifier.citationBioscience Journal, v. 28, n. 4, p. 660-666, 2012.
dc.identifier.issn1516-3725
dc.identifier.issn1981-3163
dc.identifier.scopus2-s2.0-84867797626
dc.identifier.urihttp://hdl.handle.net/11449/232104
dc.language.isoeng
dc.language.isopor
dc.relation.ispartofBioscience Journal
dc.sourceScopus
dc.subjectBone mineral density
dc.subjectBone stiffness
dc.subjectOsteopenia
dc.titleAtividade livre na caixa associada ao ganho de peso e restauração das propriedades estruturais e mecânicas de osso em ratos jovens após hiposinesia de membros pélvicospt
dc.title.alternativeFree activity in the cage associated with body weight and restoration of bone structural and mechanical properties in growing rats after hindlimb unloadingen
dc.typeArtigo

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