Effect of allopurinol on the kidney function, histology and injury biomarker (NGAL, IL 18) levels in uninephrectomised rats subjected to ischaemia-reperfusion injury

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dc.contributor.authorBussmann, André Roberto
dc.contributor.authorMarton Filho, Marcos Antônio
dc.contributor.authorMódolo, Marília Pinheiro
dc.contributor.authorMódolo, Renata Pinheiro
dc.contributor.authorAmado, Patrícia
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionABC Medical School
dc.date.accessioned2015-02-02T12:39:34Z
dc.date.available2015-02-02T12:39:34Z
dc.date.issued2014-08-01
dc.description.abstractPURPOSE: To investigate whether allopurinol exerts a protective effect on kidneys by measuring new kidney injury biomarkers (NGALp, NGALu, KIM 1 and IL 18) and analysing the renal function and histology in uninephrectomised rats subjected to ischaemia-reperfusion injury. METHODS: Thirty two Wistar rats were randomly allocated to four groups: Sham (S): laparotomy; Control (C): laparotomy and ischaemia-reperfusion in the left kidney; Control Allopurinol (CA): laparotomy and allopurinol at a dose of 100mg·kg 1·d 1; and Allopurinol (A): laparotomy ischaemia-reperfusion in the left kidney and allopurinol at a dose of 100mg·kg 1·d 1. The NGALp, NGALu, KIM 1, IL 18 and creatinine levels and the kidney histology were analysed. The significance level was established as p<0.05. RESULTS: Creatinine level increased in all the groups, with A ≈ C > S ≈ CA. The NGALp, NGALu and IL 18 levels exhibited similar behaviour in all the groups. KIM 1 was higher in group A than C and showed intermediate values in groups S and CA. Severity of injury in the left kidney was greater in groups C and A compared to S and CA. CONCLUSION: Allopurinol did not exert protective or damaging effects on the kidneys of rats subjected to ischaemia-reperfusion injury.en
dc.description.affiliationSao Paulo State University Botucatu Medical School
dc.description.affiliationUNESP Botucatu Medical School
dc.description.affiliationABC Medical School
dc.description.affiliationUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUNESP Botucatu Medical School Department of Anaesthesiology
dc.description.affiliationUnespSao Paulo State University Botucatu Medical School
dc.description.affiliationUnespUNESP Botucatu Medical School
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anaesthesiology
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent515-521
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502014000800006
dc.identifier.citationActa Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 29, n. 8, p. 515-521, 2014.
dc.identifier.doi10.1590/S0102-86502014000800006
dc.identifier.fileS0102-86502014000800515.pdf
dc.identifier.issn0102-8650
dc.identifier.lattes8223546475724058
dc.identifier.lattes0585723113037140
dc.identifier.scieloS0102-86502014000800515
dc.identifier.urihttp://hdl.handle.net/11449/114483
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.subjectIschemiaen
dc.subjectAcute Kidney Injuryen
dc.subjectAllopurinolen
dc.subjectInterleukin-18en
dc.subjectBiomarkers, Pharmacologicalen
dc.subjectRatsen
dc.titleEffect of allopurinol on the kidney function, histology and injury biomarker (NGAL, IL 18) levels in uninephrectomised rats subjected to ischaemia-reperfusion injuryen
dc.typeArtigo
unesp.author.lattes8223546475724058
unesp.author.lattes0585723113037140
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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