Effect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats - Morphometric Study

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dc.contributor.authorAccioly, Marilita Falangola
dc.contributor.authorSouza, Doroteia Rossi Silva
dc.contributor.authorTrevizan Padulla, Susimary Aparecida [UNESP]
dc.contributor.authorCamargo Filho, José Carlos Silva [UNESP]
dc.contributor.authorCarmo, Edna Maria do [UNESP]
dc.contributor.authorMartins, Alex Tadeu
dc.contributor.authorBrandao, Antonio Carlos
dc.contributor.authorAzoubel, Reinaldo
dc.contributor.institutionUniversidade Federal do Triângulo Mineiro (UFTM)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv Ctr Educ Fundat Barretos UNIFEB
dc.date.accessioned2014-12-03T13:11:40Z
dc.date.available2014-12-03T13:11:40Z
dc.date.issued2013-12-01
dc.description.abstractThe present study was carried out to evaluate the effect of statins associated with physical exercise (PE) in liver cells in dyslipidemic rats through cariometry. The animals were divided into six groups: animals subjected to a hypercholesterolemic diet (HD), simvastatin, with (G1) and without (G2) physical exercise (PE); HD submitted (G3) or not (G4) to PE, and commercial food diet (F) with (G5) and without (G6) PE. Histological analysis of the liver was performed by staining the slides with hematoxylin and eosin. The cariometric study included measuring the major and minor diameters of the hepatocytes nuclei. The Shapiro-Wilk test was also performed. To determine the differences among the groups, the Kruskal-Wallis Test with Dunn's post-test were conducted. The significance level was set at 5%. No difference was found in the hepatocytes nuclei between G5 and G6. When these groups were related with G3 and G4, reduced nuclei were observed. There was no difference between G1 and G6. The comparison between G6 and G2 showed that the nuclei in G2 were smaller. No difference was detected between G5 and G1. Changes were observed in the nuclei shape in G2 in comparison to G1. Considering G2 and G3, a decrease in the size of nuclei was observed in G3. On the other hand, G2 showed changes in shape in the comparative analysis with G4. The size and shape of G1 nuclei were larger than G3 as well as changes in shape were observed when compared to G4. G4 showed smaller nuclei than G3. Therefore, F, associated or not with the practice of PE, does not alter the size and shape of the hepatocytes nuclei; HD combined with sedentarism influences changes in the morphometric parameters of hepatocytes; and the association of simvastatin and PE seems to protect the hepatocytes nuclei with regard to HD.en
dc.description.affiliationUniv Fed Triangulo Mineiro, Dept Appl Phys Therapy, Uberaba, MG, Brazil
dc.description.affiliationFac Med Sao Jose Rio Preto FAMERP, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFCT UNESP, Dept Phys Therapy, Campus Presidente Pruden, SP, Brazil
dc.description.affiliationUniv Ctr Educ Fundat Barretos UNIFEB, Program Dent Sci, Barretos, SP, Brazil
dc.description.affiliationFac Med Sao Jose Rio Preto FAMERP, Hlth Sci Program, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespFCT UNESP, Dept Phys Therapy, Campus Presidente Pruden, SP, Brazil
dc.format.extent1309-1316
dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000400026
dc.identifier.citationInternational Journal of Morphology. Temuco: Soc Chilena Anatomia, v. 31, n. 4, p. 1309-1316, 2013.
dc.identifier.fileS0717-95022013000400026.pdf
dc.identifier.issn0717-9502
dc.identifier.lattes6966228767013159
dc.identifier.scieloS0717-95022013000400026
dc.identifier.urihttp://hdl.handle.net/11449/113392
dc.identifier.wosWOS:000332286400026
dc.language.isoeng
dc.publisherSoc Chilena Anatomia
dc.relation.ispartofInternational Journal of Morphology
dc.relation.ispartofjcr0.336
dc.relation.ispartofsjr0,207
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectSimvastatinen
dc.subjectExerciseen
dc.subjectDieten
dc.subjectCariometryen
dc.titleEffect of Statins and Aerobic Physical Exercise on Liver Function in Dyslipidemic Rats - Morphometric Studyen
dc.typeArtigo
dcterms.rightsHolderSoc Chilena Anatomia
unesp.author.lattes6966228767013159[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências e Tecnologia, Presidente Prudentept

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