Natural latex films as carrier for casearia sylvestris swartz extract associated with ciprofloxacin

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dc.contributor.authorBolognesi, Luis Felipe Cesar [UNESP]
dc.contributor.authorBorges, Felipe Azevedo [UNESP]
dc.contributor.authorCinman, José Luiz Ferreira [UNESP]
dc.contributor.authorSilva, Rosângela Gonçalves da [UNESP]
dc.contributor.authorSantos, André Gonzaga dos [UNESP]
dc.contributor.authorHerculano, Rondinelli Donizetti [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-08-21T17:53:10Z
dc.date.available2015-08-21T17:53:10Z
dc.date.issued2015
dc.description.abstractIn order to create a new sustained drug delivery system applied for tissue regeneration, this study beget a natural rubber latex (NRL) film with Casearia sylvestris extract and ciprofloxacin. Manipulated from the biomaterial latex obtained by the rubber tree Hevea brasiliensis, the NRL film has shown to be a great angiogenic compound and also has shown a great potential in being a possible carrier for sustained drug release. In order to increase the therapeutic spectrum of the film two substances was added to it: the C. sylvestris extract which has antiulcer, anti-inflammatory and wound healing effects due to its casearins and the antibiotic ciprofloxacin which is considered as one of the main drugs used for open wounds in the skin. The study occurred at State São Paulo University in Assis (UNESP-FCL), Brazil. The substances were mixed and a film was made by casting at ambient temperature creating circular films with 5cm of diameter. After that the film was placed in 1 liter of water to start the release study. The release behavior was analyzed by UV-VIS spectrophotometry being the casearins related to the wavelength of 235nm and the ciprofloxacin of 320nm. The film supported the release of compounds, releasing 93.73% of the extract and 56.53% of the drug, along 29 hours. In addition, the incorporation was proven by Scanning Electron Microscopy (SEM), which showed the morphology of pure and incorporated films and also by Fourier Transform Infrared Spectroscopy (FTIR) which has shown that no chemical change occurred during the process. Thereby, according to results, the material has a possible approach to biomedical application.en
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Faculdade de Araraquara - Ciências Farmacêuticas, Centro, CEP 14801902, SP, Brasil
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Faculdade de Araraquara - Ciências Farmacêuticas, Centro, CEP 14801902, SP, Brasil
dc.description.sponsorshipPró-Reitoria de Pesquisa (PROPe)
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdPROPe: 05/11
dc.description.sponsorshipIdFUNDUNESP: 193/2011
dc.description.sponsorshipIdFAPESP: 2012/14518-9
dc.description.sponsorshipIdFAPESP: 2011/17411-8
dc.format.extent17-25
dc.identifierhttp://www.sciencedomain.org/abstract/6072
dc.identifier.citationAmerican Chemical Science Journal, v. 5, n. 1, p. 17-25, 2015.
dc.identifier.doi10.9734/ACSJ/2015/12263
dc.identifier.fileISSN2249-0205-2015-05-01-17-25.pdf
dc.identifier.issn2249-0205
dc.identifier.lattes5743408042753244
dc.identifier.urihttp://hdl.handle.net/11449/126786
dc.language.isoeng
dc.relation.ispartofAmerican Chemical Science Journal
dc.rights.accessRightsAcesso aberto
dc.sourceCurrículo Lattes
dc.subjectSustained releaseen
dc.subjectLatexen
dc.subjectCasearia sylvestrisen
dc.subjectCiprofloxacinen
dc.subjectBiomaterialsen
dc.subjectCasearia sylvestris Swartzpt
dc.subjectCiprofloxacinpt
dc.subjectNatural rubberpt
dc.titleNatural latex films as carrier for casearia sylvestris swartz extract associated with ciprofloxacinen
dc.typeArtigo
unesp.author.lattes5743408042753244
unesp.author.lattes4000625974516852[5]
unesp.author.orcid0000-0002-4920-2506[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologiapt

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