A soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinoma

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dc.contributor.authorKinouchi, Fernanda Lopes [UNESP]
dc.contributor.authorGeraldo Maia, Danielle Cardoso [UNESP]
dc.contributor.authorde Abreu Ribeiro, Livia Carolina [UNESP]
dc.contributor.authorPolesi Placeres, Marisa Campos [UNESP]
dc.contributor.authorFont de Valdez, Graciela
dc.contributor.authorLuis Colombo, Lucas
dc.contributor.authorRossi, Elizeu Antonio [UNESP]
dc.contributor.authorCarlos, Iracilda Zeppone [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCentro de Referencia para Lactobacilos (CERELA)
dc.date.accessioned2014-05-20T13:23:42Z
dc.date.available2014-05-20T13:23:42Z
dc.date.issued2012-11-01
dc.description.abstractPurpose: Soy and its fermented products are considered functional foods. The study objective was to assess three functional food - a non-fermented soy product (NFP), fermented soy product (FSP), fermented soy product enriched with isoflavones (FI) - in terms of their ability to reduce the development of adenocarcinoma in mice, as well their ability on modulating immune system.Methods: It was observed tumor volume and to verify correlations with the immune system it was measured levels of the cytokines IL-1 beta and TNF-alpha produced by macrophages as well as IFN-gamma produced by lymphocytes using ELISA test, and nitric oxide production by macrophages using Griess reagent.Results: All products showed immunological activity, but FSP showed the most effective tumor containment, resulting in smallest tumor volumes. Fl animals expressed larger amounts of nitric oxide and IL-1 beta and exhibited larger tumor sizes than FSP and NFP animals.Conclusions: The results suggested that the ingestion of FSP was most efficient in tumor containment, possibly due to a positive modulation of the immune system by when Enterococcus faecium and Lactobacillus helveticus are added to the soy product. (C) 2012 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.affiliationCtr Referencia Lactobacilos, San Miguel de Tucuman, Argentina
dc.description.affiliationInst Oncol Angel H Roffo, Buenos Aires, DF, Argentina
dc.description.affiliationUnespUniv Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent4144-4148
dc.identifierhttp://dx.doi.org/10.1016/j.fct.2012.08.038
dc.identifier.citationFood and Chemical Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 50, n. 11, p. 4144-4148, 2012.
dc.identifier.doi10.1016/j.fct.2012.08.038
dc.identifier.issn0278-6915
dc.identifier.lattes3242858535763793
dc.identifier.lattes1730146818754269
dc.identifier.urihttp://hdl.handle.net/11449/7201
dc.identifier.wosWOS:000310654300038
dc.language.isoeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relation.ispartofFood and Chemical Toxicology
dc.relation.ispartofjcr3.977
dc.relation.ispartofsjr1,144
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectSoyen
dc.subjectIsoflavonesen
dc.subjectCytokineen
dc.subjectCanceren
dc.subjectImmune systemen
dc.titleA soy-based product fermented by Enterococcus faecium and Lactobacillus helveticus inhibits the development of murine breast adenocarcinomaen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderPergamon-Elsevier B.V. Ltd
unesp.author.lattes3242858535763793
unesp.author.lattes1730146818754269
unesp.author.orcid0000-0002-0084-3468[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Ciências Farmacêuticas, Araraquarapt

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