Treatment of adriamycin-induced nephropathy with erythropoietin and G-CSF

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dc.contributor.authorAndrade, Luís Gustavo Modelli de [UNESP]
dc.contributor.authorMarlene Viero, Rosa [UNESP]
dc.contributor.authorCordeiro de Carvalho, Maria Fernanda [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:29:05Z
dc.date.available2014-05-27T11:29:05Z
dc.date.issued2013-05-01
dc.description.abstractBackground: Granulocyte colony-stimulating factor (G-CSF) and Erythropoietin (EPO) are known to stimulate the growth and differentiation of progenitor cells to prevent acute renal injury. This study aimed to assess the use of growth factors to mobilize stem cell in a mouse model of adriamycin-induced chronic kidney disease. Methods: All animals were injected with adriamycin for kidney injury and allocated into three treatment groups (G-CSF, EPO and G-CSF + EPO), and a control group (adriamycin alone). Results: Number of atrophic sites, glomerulosclerosis rate and interstitial fibrosis severity score were assessed in all groups. In all treatment groups, histologic parameters did not significantly differ, but were lower than in the control group (P<.001). Scal and CD34 expressions among treatment groups showed no statistically significant difference, but were higher than in the control group (P<.0001). CD105 expression was higher in EPO and G+EPO as compared to G-CSF and the control group (P<.0001), with no statistically significant difference between the latter two groups (P = NS). Conclusion: G-CSF and EPO had a histologic protective effect, while treatment with EPO + G-CSF had no additive effects in a model of adriamycin-induced chronic kidney disease. © 2013 Societá Italiana di Nefrologia.en
dc.description.affiliationDepartment of Internal Medicine - UNESP Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationDepartment of Pathology - UNESP Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Internal Medicine - UNESP Universidade Estadual Paulista, Botucatu, SP
dc.description.affiliationUnespDepartment of Pathology - UNESP Universidade Estadual Paulista, Botucatu, SP
dc.format.extent534-539
dc.identifierhttp://dx.doi.org/10.5301/jn.5000200
dc.identifier.citationJournal of Nephrology, v. 26, n. 3, p. 534-539, 2013.
dc.identifier.doi10.5301/jn.5000200
dc.identifier.issn1121-8428
dc.identifier.issn1724-6059
dc.identifier.lattes1453564171333848
dc.identifier.scopus2-s2.0-84877987195
dc.identifier.urihttp://hdl.handle.net/11449/75315
dc.identifier.wosWOS:000322053900016
dc.language.isoeng
dc.relation.ispartofJournal of Nephrology
dc.relation.ispartofjcr2.724
dc.relation.ispartofsjr1,003
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAdriamycin
dc.subjectErythropoietin
dc.subjectG-CSF
dc.subjectMobilization
dc.subjectNephropathy
dc.subjectStem cell
dc.subjectalfaepoetina
dc.subjectataxin 1
dc.subjectCD34 antigen
dc.subjectdoxorubicin
dc.subjectendoglin
dc.subjectrecombinant erythropoietin
dc.subjectrecombinant granulocyte colony stimulating factor
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectatrophy
dc.subjectchronic kidney disease
dc.subjectcontrolled study
dc.subjectdisease severity
dc.subjectdrug effect
dc.subjectglomerulosclerosis
dc.subjecthistopathology
dc.subjectkidney fibrosis
dc.subjectmale
dc.subjectmouse
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectrenal protection
dc.subjectscoring system
dc.subjectstem cell mobilization
dc.titleTreatment of adriamycin-induced nephropathy with erythropoietin and G-CSFen
dc.typeArtigo
dcterms.licensehttp://www.vascular-access.info/public/JVA/About/static_copyright_transfer.aspx
unesp.author.lattes1453564171333848
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina, Botucatupt

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